ArticlePloS one2015
Transcriptome Profiling and Molecular Pathway Analysis of Genes in Association with Salinity Adaptation in Nile Tilapia Oreochromis niloticus.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Dietary mannitol improves salinity adaptation in Nile tilapia (Oreochromis niloticus) by enhancing ion regulation, energy metabolism and antioxidant defense.Fish physiology and biochemistry · 2026Article
- Integrated Transcriptomic and Proteomic Analyses Reveal Stage-Dependent Gill Remodeling Under Chronic Salinity Stress in Grass Carp (Ctenopharyngodon idella).Marine biotechnology (New York, N.Y.) · 2026Article
- Multi-Omics Analysis Provides Insights into the Key Regulatory Pathways of Energy Metabolism in GIFT Under Salinity Stress.Veterinary sciences · 2026Article
- Transcriptomic Analysis ofAnimals : an open access journal from MDPI · 2025Article
- Article
- Aquatic Organisms in Response to Salinity Stress: Ecological Impacts, Adaptive Mechanisms, and Resilience Strategies.Biology · 2025Review
- Comparative toxicotranscriptomics of longterm cypermethrin exposure to aquacultured fish Labeo catla (Catla).Scientific reports · 2025Article
- Interactive effects of salinity and dietary lipid sources on growth, hepatic lipid metabolism, and transcriptomic profiles in spotted sea bass (Frontiers in physiology · 2025Article
- Feeding Behavior, Gut Microbiota, and Transcriptome Analysis Reveal Individual Growth Differences in the Sea UrchinBiology · 2024Article
- Effects of Different Salinity Stress on the Transcriptomic Responses of Freshwater Crayfish (Biology · 2024Article
- Genomic insights into the seawater adaptation in Cyprinidae.BMC biology · 2024Article
- Effects of Diets With Different Carbohydrate to Lipid Ratios on the Growth Performance, Ion Transport, and Carbohydrate, Lipid and Ammonia Metabolism of Nile Tilapia (Aquaculture nutrition · 2024Article
- Article
- Effects of Dietary Folic Acid Supplementation on Sex Differences in Oriental River Prawn,Animals : an open access journal from MDPI · 2023Article
- RNA Sequencing (RNA-Seq) Analysis Reveals Liver Lipid Metabolism Divergent Adaptive Response to Low- and High-Salinity Stress in Spotted Scat (Animals : an open access journal from MDPI · 2023Article
- The Modulation of Immune Responses inViruses · 2023Article
- Whole Transcriptome Analysis of Differentially Expressed Genes in Cultured Nile Tilapia (Genes · 2023Article
- RNA-seq Analysis Reveals Alternative Splicing Under Heat Stress in Rainbow Trout (Oncorhynchus mykiss).Marine biotechnology (New York, N.Y.) · 2022Article
- RNA Sequencing Analysis Reveals Divergent Adaptive Response to Hypo- and Hyper-Salinity in Greater Amberjack (Animals : an open access journal from MDPI · 2022Article
- Mechanisms of NaFrontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nile tilapia Oreochromis niloticus is a freshwater fish but can tolerate a wide range of salinities. The mechanism of salinity adaptation at the molecular level was studied using RNA-Seq to explore the molecular pathways in fish exposed to 0, 8, or 16 (practical salinity unit, psu). Based on the change of gene expressions, the differential genes unions from freshwater to saline water were classified into three categories. In the constant change category (1), steroid biosynthesis, steroid hormone biosynthesis, fat digestion and absorption, complement and coagulation cascades were significantly affected by salinity indicating the pivotal roles of sterol-related pathways in response to salinity stress. In the change-then-stable category (2), ribosomes, oxidative phosphorylation, signaling pathways for peroxisome proliferator activated receptors, and fat digestion and absorption changed significantly with increasing salinity, showing sensitivity to salinity variation in the environment and a responding threshold to salinity change. In the stable-then-change category (3), protein export, protein processing in endoplasmic reticulum, tight junction, thyroid hormone synthesis, antigen processing and presentation, glycolysis/gluconeogenesis and glycosaminoglycan biosynthesis-keratan sulfate were the significantly changed pathways, suggesting that these pathways were less sensitive to salinity variation. This study reveals fundamental mechanism of the molecular response to salinity adaptation in O. niloticus, and provides a general guidance to understand saline acclimation in O. niloticus.
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