Evidence map›Paper›PMID 26305520›Full record

ReviewAmerican journal of respiratory and critical care medicine2015

Future Research Directions in Asthma. An NHLBI Working Group Report.

Bruce D Levy, Patricia J Noel, Michelle M Freemer, Michelle M Cloutier, Steve N Georas, Nizar N Jarjour, Carole Ober, Prescott G Woodruff, Kathleen C Barnes, Bruce G Bender and 20 more

Abstract readReview
In one paragraph

Review in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Individualized therapy for persistent asthma in young children.The Journal of allergy and clinical immunology · 2016
    Trial
  5. Article
  6. Distinctive CD39Nature communications · 2024
    Article
  7. Review
  8. Advancing Exposomic Research in Prenatal Respiratory Disease Programming.Immunology and allergy clinics of North America · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Holy Grail: the journey towards disease modification in asthma.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  13. Review
  14. Observational
  15. Review
  16. Scavenger Receptor BI Attenuates IL-17A-Dependent Neutrophilic Inflammation in Asthma.American journal of respiratory cell and molecular biology · 2021
    Article
  17. Article
  18. Review
  19. MicroRNA Targets for Asthma Therapy.Advances in experimental medicine and biology · 2021
    Article
  20. miR-135a inhibits airway inflammatory response in asthmatic mice via regulating JAK/STAT signaling pathway.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Bruce D Levy1 Brigham and Women's Hospital, Boston, Massachusetts.
Patricia J Noel2 National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Michelle M Freemer2 National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Michelle M Cloutier3 University of Connecticut Health Center, Hartford, Connecticut.
Steve N Georas4 University of Rochester, Rochester, New York.
Nizar N Jarjour5 University of Wisconsin Hospital and Clinics, Madison, Wisconsin.
Carole Ober6 The University of Chicago, Chicago, Illinois.
Prescott G Woodruff7 University of California at San Francisco, San Francisco, California.
Kathleen C Barnes8 Johns Hopkins University, Baltimore, Maryland.
Bruce G Bender9 National Jewish Health, Denver, Colorado.
Carlos A Camargo10 Massachusetts General Hospital, Boston, Massachusetts.
Geoff L Chupp11 Yale University School of Medicine, New Haven, Connecticut.
Loren C Denlinger5 University of Wisconsin Hospital and Clinics, Madison, Wisconsin.
John V Fahy7 University of California at San Francisco, San Francisco, California.
Anne M Fitzpatrick12 Emory University School of Medicine, Atlanta, Georgia.
Anne Fuhlbrigge1 Brigham and Women's Hospital, Boston, Massachusetts.
Ben M Gaston13 Case Western Reserve University, Cleveland, Ohio.
Tina V Hartert14 Vanderbilt University School of Medicine, Nashville, Tennessee.
Jay K Kolls15 University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Susan V Lynch7 University of California at San Francisco, San Francisco, California.
Wendy C Moore16 Wake Forest School of Medicine, Winston Salem, North Carolina.
Wayne J Morgan17 University of Arizona, Tucson, Arizona.
Kari C Nadeau18 Stanford School of Medicine, Stanford, California.
Dennis R Ownby19 Georgia Regents University, Augusta, Georgia.
Julian Solway6 The University of Chicago, Chicago, Illinois.
Stanley J Szefler20 Children's Hospital Colorado and the University of Colorado School of Medicine, Denver, Colorado.
Sally E Wenzel15 University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Rosalind J Wright21 Icahn School of Medicine at Mount Sinai, New York, New York; and.
Robert A Smith2 National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Serpil C Erzurum22 Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio.

Funding

Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Specialized Pro-Resolving Mediators in AsthmaR01HL122531 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEVY, BRUCE D · 2014 to 2024
$4.7M
Longitudinal Analysis of Transcriptomic Endophenotypes in AsthmaR01HL118346 · NHLBI · YALE UNIVERSITY · PI CHUPP, GEOFFREY L · 2013 to 2016
$3.3M
Midcareer Investigator Patient-oriented Research Award in Bronchiolitis & AsthmaK24AI077930 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTERT, TINA V · 2008 to 2017
$1.6M
NCATS NIH HHS UL1 TR000430NHLBI NIH HHS P01 HL107202NHLBI NIH HHS R01 HL118346NHLBI NIH HHS R01 HL122531NIAID NIH HHS K24 AI077930
6 · The paper itself

Abstract

Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the NHLBI convened a group of extramural investigators for an Asthma Research Strategic Planning workshop on September 18-19, 2014, to accelerate discoveries and their translation to patients. The workshop focused on (1) in utero and early-life origins of asthma, (2) the use of phenotypes and endotypes to classify disease, (3) defining disease modification, (4) disease management, and (5) implementation research. This report summarizes the workshop and produces recommendations to guide future research in asthma.

Indexed as

National Heart, Lung, and Blood Institute (U.S.)ResearchAsthmaEducationHumansUnited Statesasthmadisease modificationimplementationphenotypeprevention

Identifiers

PMID26305520
PMCPMC4731702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.