ReviewSeminars in thrombosis and hemostasis2015
Thrombosis and Hemorrhage in Diabetic Retinopathy: A Perspective from an Inflammatory Standpoint.
Review in Seminars in thrombosis and hemostasis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Deep learning-based optical coherence tomography and retinal images for detection of diabetic retinopathy: a systematic and meta analysis.Frontiers in endocrinology · 2025Pooled it
- Patient and Physician Perspectives on Oral Treatment in Ophthalmology.Ophthalmology and therapy · 2026Article
- Retinal microvascular changes on retinal photographs for predicting stroke recurrence: a systematic review and meta-analysis.Eye (London, England) · 2026Article
- Association between peripheral blood biomarkers and diabetic macular edema.Acta diabetologica · 2026Article
- Integrative transcriptomic and machine learning analysis identifies key extracellular matrix-related genes in diabetic retinopathy.Scientific reports · 2026Article
- Regulatory mechanisms of Traditional Chinese Medicine on gut microbiota in diabetic microvascular complications.Chinese medicine · 2026Review
- Knowledge distillation-based lightweight MobileNet model for diabetic retinopathy classification.Scientific reports · 2025Article
- Targeting NLRP3/caspase-1/GSDMD to treat inner ear injury from labyrinthine hemorrhage.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Diabetic retinopathy screening using machine learning: a systematic review.BMC biomedical engineering · 2025Article
- Prognostic Role of TSH Within Euthyroid T2DM Patients with Retinopathy: A 3-Year Cohort Study.Diseases (Basel, Switzerland) · 2025Article
- Comparison of the Risk of Diabetic Retinopathy Between Sodium-Glucose Cotransporter-2 Inhibitors and Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes Mellitus in Japan: A Retrospective Analysis of Real-World Data.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Article
- Relationship between macular perfusion and lesion distribution in diabetic retinopathy.Eye (London, England) · 2024Observational
- Next generation therapeutics for retinal neurodegenerative diseases.Journal of controlled release : official journal of the Controlled Release Society · 2024Review
- Changes in Circulating Acylated Ghrelin and Neutrophil Elastase in Diabetic Retinopathy.Medicina (Kaunas, Lithuania) · 2024Article
- Case reports: Intraoperative migratory retinal venous thrombus in proliferative diabetic retinopathy.Frontiers in medicine · 2024Article
- Vasoinhibin's Apoptotic, Inflammatory, and Fibrinolytic Actions Are in a Motif Different From Its Antiangiogenic HGR Motif.Endocrinology · 2023Article
- Enhancement of Diabetic Retinopathy Prognostication Using Deep Learning, CLAHE, and ESRGAN.Diagnostics (Basel, Switzerland) · 2023Article
- Deep Learning-Based Prediction of Diabetic Retinopathy Using CLAHE and ESRGAN for Enhancement.Healthcare (Basel, Switzerland) · 2023Article
- ITGA2 Gene Polymorphism Is Associated with Type 2 Diabetes Mellitus in the Kazakhstan Population.Medicina (Kaunas, Lithuania) · 2022Article
- Three-Dimensional Semantic Segmentation of Diabetic Retinopathy Lesions and Grading Using Transfer Learning.Journal of personalized medicine · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Retinal ischemia and hemorrhage are hallmarks of worsening diabetic retinopathy, which can lead to neovascularization, macular edema, and severe vision loss. Although diabetes alters expression of clotting factors and their activities, and increases retinal microthromboses, the effects of thrombotic processes on the pathogenesis of diabetic retinopathy are not fully understood. In addition to the roles of coagulation and fibrinolytic cascades in thrombosis and hemostasis, components in these systems also mediate multiple effects on the vasculature that promote inflammation. Plasma kallikrein, thrombin, and urokinase are increased in diabetic retinopathy, and exert proinflammatory effects that contribute to retinal vascular dysfunction. The accumulation and activation of these and additional coagulation factors in the vitreous due to hemorrhage and chronic retinal injury in the diabetic retina may contribute to worsening of retinal inflammation and capillary dysfunction, which lead to retinal ischemia and edema. Further understanding of the role for specific coagulation factors in diabetic retinopathy may suggest new therapeutic opportunities for this vision-threatening disease.
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