Evidence map›Paper›PMID 26305189›Full record

ReviewNanomedicine (London, England)2015

Antimicrobial photodynamic inactivation in nanomedicine: small light strides against bad bugs.

Rui Yin, Tanupriya Agrawal, Usman Khan, Gaurav K Gupta, Vikrant Rai, Ying-Ying Huang, Michael R Hamblin

RetractedOpen access · greenAbstract readReviewRetracted Publication
In one paragraph

Review in Nanomedicine (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 168 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Photodynamic Inactivation ofBiomacromolecules · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Porphyrin Photosensitizers Grafted in Cellulose Supports: A Review.International journal of molecular sciences · 2023
    Review
  10. Review
  11. Article
  12. Recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022
    Review
  13. Review
  14. Review
  15. Enhanced Eradication ofFrontiers in microbiology · 2022
    Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Rui YinDepartment of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Tanupriya AgrawalWellman Center for Photomedicine, Massachusetts General Hospital, BAR414, 40 Blossom Street, Boston, MA 02114, USA.
Usman KhanWellman Center for Photomedicine, Massachusetts General Hospital, BAR414, 40 Blossom Street, Boston, MA 02114, USA.
Gaurav K GuptaWellman Center for Photomedicine, Massachusetts General Hospital, BAR414, 40 Blossom Street, Boston, MA 02114, USA.
Vikrant RaiWilf Family Cardiovascular Research Institute, Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
Ying-Ying HuangWellman Center for Photomedicine, Massachusetts General Hospital, BAR414, 40 Blossom Street, Boston, MA 02114, USA.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital, BAR414, 40 Blossom Street, Boston, MA 02114, USA.
Harvard University · USAlbert Einstein College of Medicine · US

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
NIAID NIH HHS R01 AI050875
6 · The paper itself

Abstract

The relentless advance of drug-resistance among pathogenic microbes, mandates a search for alternative approaches that will not cause resistance. Photodynamic inactivation (PDI) involves the combination of nontoxic dyes with harmless visible light to produce reactive oxygen species that can selectively kill microbial cells. PDI can be broad-spectrum in nature and can also destroy microbial cells in biofilms. Many different kinds of nanoparticles have been studied to potentiate antimicrobial PDI by improving photosensitizer solubility, photochemistry, photophysics and targeting. This review will cover photocatalytic disinfection with titania nanoparticles, carbon nanomaterials (fullerenes, carbon nanotubes and graphene), liposomes and polymeric nanoparticles. Natural polymers (chitosan and cellulose), gold and silver plasmonic nanoparticles, mesoporous silica, magnetic and upconverting nanoparticles have all been used for PDI.

Indexed as

LightNanomedicinePhotochemotherapyBacteriaCatalysisMicrobial Sensitivity Testsbacteriacarbon nanomaterialsfungiliposomesphotodynamic therapyphotoinactivationphotosensitizertitania photocatalysisupconversion

Identifiers

PMID26305189
PMCPMC4557875
OpenAlexW1938595213

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.