ArticleThe ISME journal2016
Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections.
Article in The ISME journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed, 145 citations in OpenAlex.
- AcceleratingProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Comprehensive genomic insights into lineages, virulence, and antibiotic resistance profiles of Campylobacter jejuni entailing a global One Health scenario.Gut pathogens · 2026Article
- Geographic clustering and population structures ofMicrobial genomics · 2026Article
- Consequences ofMicroorganisms · 2026Article
- Cross-Host Adaptation ofMicroorganisms · 2026Article
- Identification of a core set ofMicrobiology (Reading, England) · 2026Article
- Seasonal dynamics, antimicrobial resistance, and genetic lineages of thermotolerantScience in One Health · 2026Article
- Genomic epidemiology and the evolution ofMicrobial genomics · 2025Article
- Pangenomic Characterization ofPathogens (Basel, Switzerland) · 2025Article
- Article
- New Campylobacter Lineages in New Zealand Freshwater: Pathogenesis and Public Health Implications.Environmental microbiology · 2024Article
- Machine learning to attribute the source of Campylobacter infections in the United States: A retrospective analysis of national surveillance data.The Journal of infection · 2024Article
- Five centuries of genome evolution and multi-host adaptation ofMicrobial genomics · 2024Article
- Article
- Genomic tailoring of autogenous poultry vaccines to reduce Campylobacter from farm to fork.NPJ vaccines · 2024Article
- Article
- Inference of Infectious Disease Transmission through a Relaxed Bottleneck Using Multiple Genomes Per Host.Molecular biology and evolution · 2024Article
- Use of whole genome sequencing for surveillance and control of foodborne diseases:Frontiers in microbiology · 2024Review
- Effects of rearing systems (cage versus floor) on the microbial composition and transcriptome of goose ileum.Frontiers in veterinary science · 2024Article
- Prevalence, antibiotic resistance, and genomic characterisation ofMicrobial genomics · 2024Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Campylobacter jejuni and Campylobacter coli are the biggest causes of bacterial gastroenteritis in the developed world, with human infections typically arising from zoonotic transmission associated with infected meat. Because Campylobacter is not thought to survive well outside the gut, host-associated populations are genetically isolated to varying degrees. Therefore, the likely origin of most strains can be determined by host-associated variation in the genome. This is instructive for characterizing the source of human infection. However, some common strains, notably isolates belonging to the ST-21, ST-45 and ST-828 clonal complexes, appear to have broad host ranges, hindering source attribution. Here whole-genome sequencing has the potential to reveal fine-scale genetic structure associated with host specificity. We found that rates of zoonotic transmission among animal host species in these clonal complexes were so high that the signal of host association is all but obliterated, estimating one zoonotic transmission event every 1.6, 1.8 and 12 years in the ST-21, ST-45 and ST828 complexes, respectively. We attributed 89% of clinical cases to a chicken source, 10% to cattle and 1% to pig. Our results reveal that common strains of C. jejuni and C. coli infectious to humans are adapted to a generalist lifestyle, permitting rapid transmission between different hosts. Furthermore, they show that the weak signal of host association within these complexes presents a challenge for pinpointing the source of clinical infections, underlining the view that whole-genome sequencing, powerful though it is, cannot substitute for intensive sampling of suspected transmission reservoirs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.