ArticleScientific reports2015
Radiant energy required for infrared neural stimulation.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Optical induction of auditory perception via cochlear stimulation in Mongolian gerbils without genetic modification.iScience · 2026Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- In-vitro quantitative measurement and analysis of the photosensitivity of cells to a weak pulse laser.Biomedical optics express · 2023Article
- Mapping whole brain effects of infrared neural stimulation with positron emission tomography.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Is there an unmet medical need for improved hearing restoration?EMBO molecular medicine · 2022Review
- Infrared neural stimulation at different wavelengths and pulse shapes.Progress in biophysics and molecular biology · 2021Article
- Listening to speech with a guinea pig-to-human brain-to-brain interface.Scientific reports · 2021Article
- Optimizing thermal block length during infrared neural inhibition to minimize temperature thresholds.Journal of neural engineering · 2021Article
- Near-infrared stimulation of the auditory nerve: A decade of progress toward an optical cochlear implant.Laryngoscope investigative otolaryngology · 2021Review
- Identifying optimal parameters for infrared neural stimulation in the peripheral nervous system.Neurophotonics · 2021Article
- Optical stimulation of neural tissue.Healthcare technology letters · 2020Article
- Heat transfer analysis in an uncoiled model of the cochlea during magnetic cochlear implant surgery.International journal of heat and mass transfer · 2020Article
- Towards the optical cochlear implant: optogenetic approaches for hearing restoration.EMBO molecular medicine · 2020Review
- Auditory cortical activity elicited by infrared laser irradiation from the outer ear in Mongolian gerbils.PloS one · 2020Article
- Blind Localization of Heating in Neural Tissues Induced by a Train of the Infrared Pulse Laser.Journal of lasers in medical sciences · 2019Article
- Multichannel optrodes for photonic stimulation.Neurophotonics · 2018Article
- Pressure in the Cochlea During Infrared Irradiation.IEEE transactions on bio-medical engineering · 2018Article
- Auditory Neural Activity in Congenitally Deaf Mice Induced by Infrared Neural Stimulation.Scientific reports · 2018Article
- Effect of shorter pulse duration in cochlear neural activation with an 810-nm near-infrared laser.Lasers in medical science · 2017Article
- Short-wavelength infrared laser activates the auditory neurons: comparing the effect of 980 vs. 810 nm wavelength.Lasers in medical science · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Infrared neural stimulation (INS) has been proposed as an alternative method to electrical stimulation because of its spatial selective stimulation. Independent of the mechanism for INS, to translate the method into a device it is important to determine the energy for stimulation required at the target structure. Custom-designed, flat and angle polished fibers, were used to deliver the photons. By rotating the angle polished fibers, the orientation of the radiation beam in the cochlea could be changed. INS-evoked compound action potentials and single unit responses in the central nucleus of the inferior colliculus (ICC) were recorded. X-ray computed tomography was used to determine the orientation of the optical fiber. Maximum responses were observed when the radiation beam was directed towards the spiral ganglion neurons (SGNs), whereas little responses were seen when the beam was directed towards the basilar membrane. The radiant exposure required at the SGNs to evoke compound action potentials (CAPs) or ICC responses was on average 18.9 ± 12.2 or 10.3 ± 4.9 mJ/cm(2), respectively. For cochlear INS it has been debated whether the radiation directly stimulates the SGNs or evokes a photoacoustic effect. The results support the view that a direct interaction between neurons and radiation dominates the response to INS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.