ArticleThe Journal of heredity
A Road Map for 21st Century Genetic Restoration: Gene Pool Enrichment of the Black-Footed Ferret.
Article in The Journal of heredity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 54 citations in OpenAlex.
- De-extinction technology and its application to conservation.The Journal of heredity · 2026Review
- Rapid derivation of cloning-competent cells from peripheral blood advances conservation biobanking.The Journal of heredity · 2026Article
- Chromosome-level genome of the European hamster (Cricetus cricetus) and its genome-wide population structure across Western Europe.BMC biology · 2025Article
- Towards Practical Conservation Cloning: Understanding the Dichotomy Between the Histories of Commercial and Conservation Cloning.Animals : an open access journal from MDPI · 2025Review
- Genetic load and viability of a future restored northern white rhino population.Evolutionary applications · 2024Article
- Conservation Mitonuclear Replacement: Facilitated mitochondrial adaptation for a changing world.Evolutionary applications · 2024Article
- Markers of fertility in reproductive microbiomes of male and female endangered black-footed ferrets (Mustela nigripes).Communications biology · 2024Article
- Manipulating Time by Cryopreservation: Designing an Environmental Future by Maintaining a Portal to the Past.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2024Article
- Epigenetic changes to gene pathways linked to male fertility in ex situ black-footed ferrets.Evolutionary applications · 2024Article
- Chromosome-length genome assembly and karyotype of the endangered black-footed ferret (Mustela nigripes).The Journal of heredity · 2023Article
- Reviving ghost alleles: Genetically admixed coyotes along the American Gulf Coast are critical for saving the endangered red wolf.Science advances · 2022Article
- Synthetic threads through the web of life.Proceedings of the National Academy of Sciences of the United States of America · 2021Review
- Fifty Years of Research on European MinkGenes · 2020Review
- De-Extinction.Genes · 2018Review
- Conservation of biodiversity in the genomics era.Genome biology · 2018Review
- Evaluating recovery potential of the northern white rhinoceros from cryopreserved somatic cells.Genome research · 2018Article
- Interspecies nuclear transfer using fibroblasts from leopard, tiger, and lion ear piece collected postmortem as donor cells and rabbit oocytes as recipients.In vitro cellular & developmental biology. Animal · 2016Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Interspecies somatic cell nuclear transfer (iSCNT) could benefit recovery programs of critically endangered species but must be weighed with the risks of failure. To weigh the risks and benefits, a decision-making process that evaluates progress is needed. Experiments that evaluate the efficiency and efficacy of blastocyst, fetal, and post-parturition development are necessary to determine the success or failure or species-specific iSCNT programs. Here, we use the black-footed ferret (Mustela nigripes) as a case study for evaluating this emerging biomedical technology as a tool for genetic restoration. The black-footed ferret has depleted genetic variation yet genome resource banks contain genetic material of individuals not currently represented in the extant lineage. Thus, genetic restoration of the species is in theory possible and could help reduce the persistent erosion of genetic diversity from drift. Extensive genetic, genomic, and reproductive science tools have previously been developed in black-footed ferrets and would aid in the process of developing an iSCNT protocol for this species. Nonetheless, developing reproductive cloning will require years of experiments and a coordinated effort among recovery partners. The information gained from a well-planned research effort with the goal of genetic restoration via reproductive cloning could establish a 21st century model for evaluating and implementing conservation breeding that would be applicable to other genetically impoverished species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.