Evidence map›Paper›PMID 26304905›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015

Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial.

Jun J Mao, Marjorie A Bowman, Sharon X Xie, Deborah Bruner, Angela DeMichele, John T Farrar

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 57 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 14 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03823456 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Self-acupressure for Cancer-related Symptom Cluster of Insomnia, Depression, and Anxiety in Cancer Patients: a Feasibility Randomized Controlled Trial

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2018 to 2019Enrolled114ConditionsInsomnia, Anxiety, DepressionArmsSelf-acupressure, Sham Self-acupressure
NCT05760222 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Early Acupuncture Treatment of Vasomotor Symptoms and Sleep Disorders in Breast Cancer Luteinising Hormone-releasing Hormone Analogues(LHRHa) Induced Menopause: AcuHOTFLASH Study

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2021 to 2024Enrolled90ConditionsBreast CancerArmsAcupuncture
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 14 syntheses or guidelines pooled it, 124 citations in OpenAlex.

  1. Pooled it
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  3. The use of complementary and integrative therapies as adjunct interventions during radiotherapy: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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  8. Survivorship, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2017
    Guideline
  9. Effects of non-pharmacological supportive care for hot flushes in breast cancer: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
    Pooled it
  10. Guideline
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  15. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jun J MaoJun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA. jun.mao@uphs.upenn.edu.
Marjorie A BowmanJun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.
Sharon X XieJun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.
Deborah BrunerJun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.
Angela DeMicheleJun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.
John T FarrarJun J. Mao, Sharon X. Xie, Angela DeMichele, and John T. Farrar, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Marjorie A. Bowman, Wright State University Boonshoft School of Medicine, Dayton, OH; and Deborah Bruner, Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA.
Wright State University · US

Funding

Elucidating the placebo effects of acupuncture: hot flashes as a clinical modelK23AT004112 · NCCIH · UNIVERSITY OF PENNSYLVANIA · PI MAO, JUN J · 2008 to 2012
$659k
NCCIH NIH HHS K23 AT004112NCCIH NIH HHS K23-AT004112
6 · The paper itself

Abstract

purposeHot flashes are a common and debilitating symptom among survivors of breast cancer. This study aimed at evaluating the effects of electroacupuncture (EA) versus gabapentin (GP) for hot flashes among survivors of breast cancer, with a specific focus on the placebo and nocebo effects. PATIENTS AND

methodsWe conducted a randomized controlled trial involving 120 survivors of breast cancer experiencing bothersome hot flashes twice per day or greater. Participants were randomly assigned to receive 8 weeks of EA or GP once per day with validated placebo controls (sham acupuncture [SA] or placebo pills [PPs]). The primary end point was change in the hot flash composite score (HFCS) between SA and PP at week 8, with secondary end points including group comparisons and additional evaluation at week 24 for durability of treatment effects.

resultsBy week 8, SA produced significantly greater reduction in HFCS than did PP (-2.39; 95% CI, -4.60 to -0.17). Among all treatment groups, the mean reduction in HFCS was greatest in the EA group, followed by SA, GP, and PP (-7.4 v -5.9 v -5.2 v -3.4; P = < .001). The pill groups had more treatment-related adverse events than did the acupuncture groups: GP (39.3%), PP (20.0%), EA (16.7%), and SA (3.1%), with P = .005. By week 24, HFCS reduction was greatest in the EA group, followed by SA, PP, and GP (-8.5 v -6.1 v -4.6 v -2.8; P = .002).

conclusionAcupuncture produced larger placebo and smaller nocebo effects than did pills for the treatment of hot flashes. EA may be more effective than GP, with fewer adverse effects for managing hot flashes among breast cancer survivors; however, these preliminary findings need to be confirmed in larger randomized controlled trials with long-term follow-up.

Indexed as

ElectroacupunctureAdultAgedAminesBreast NeoplasmsChemotherapy, AdjuvantCyclohexanecarboxylic AcidsFemaleGabapentingamma-Aminobutyric AcidHot FlashesHumansMiddle AgedNeedlesSurvivorsTreatment OutcomeAminesCyclohexanecarboxylic AcidsGabapentingamma-Aminobutyric Acid

Identifiers

PMID26304905
PMCPMC4622101
OpenAlexW2145582161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.