Evidence map›Paper›PMID 26304891›Full record

ReviewJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015

Collaborative Research in Childhood Cancer Survivorship: The Current Landscape.

Smita Bhatia, Saro H Armenian, Gregory T Armstrong, Eline van Dulmen-den Broeder, Michael M Hawkins, Leontien C M Kremer, Claudia E Kuehni, Jørgen H Olsen, Leslie L Robison, Melissa M Hudson

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03297034 (Swiss Childhood Cancer Survivor Study), which is not on this map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03297034 recruitingnot on this map

Swiss Childhood Cancer Survivor Study (SCCSS)

Typeobservational_patient_registrySponsorUniversity of BernRan2007 to 2050Enrolled4,136ConditionsChildhood Cancer
3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Trial
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  15. Article
  16. Measuring Biologic Resilience in Older Cancer Survivors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Review
  17. Article
  18. Article
  19. Healthcare provider perspectives on pediatric cancer survivorship care plans: a single institution pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Smita BhatiaSmita Bhatia and Saro H. Armenian, City of Hope National Medical Center, Duarte, CA; Gregory T. Armstrong, Leslie L. Robison, and Melissa M. Hudson, St Jude Children's Research Hospital, Memphis, TN; Eline van Dulmen-den Broeder, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Leontien C.M. Kremer, Academic Medical Center, Amsterdam, the Netherlands; Michael M. Hawkins, University of Birmingham, Birmingham, United Kingdom; Claudia E. Kuehni, University of Bern, Bern, Switzerland; and Jørgen H. Olsen, Danish Cancer Society Research Center, Copenhagen, Denmark. sbhatia@peds.uab.edu.
Saro H ArmenianSmita Bhatia and Saro H. Armenian, City of Hope National Medical Center, Duarte, CA; Gregory T. Armstrong, Leslie L. Robison, and Melissa M. Hudson, St Jude Children's Research Hospital, Memphis, TN; Eline van Dulmen-den Broeder, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Leontien C.M. Kremer, Academic Medical Center, Amsterdam, the Netherlands; Michael M. Hawkins, University of Birmingham, Birmingham, United Kingdom; Claudia E. Kuehni, University of Bern, Bern, Switzerland; and Jørgen H. Olsen, Danish Cancer Society Research Center, Copenhagen, Denmark.
Gregory T ArmstrongSmita Bhatia and Saro H. Armenian, City of Hope National Medical Center, Duarte, CA; Gregory T. Armstrong, Leslie L. Robison, and Melissa M. Hudson, St Jude Children's Research Hospital, Memphis, TN; Eline van Dulmen-den Broeder, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Leontien C.M. Kremer, Academic Medical Center, Amsterdam, the Netherlands; Michael M. Hawkins, University of Birmingham, Birmingham, United Kingdom; Claudia E. Kuehni, University of Bern, Bern, Switzerland; and Jørgen H. Olsen, Danish Cancer Society Research Center, Copenhagen, Denmark.
Eline van Dulmen-den BroederSmita Bhatia and Saro H. Armenian, City of Hope National Medical Center, Duarte, CA; Gregory T. Armstrong, Leslie L. Robison, and Melissa M. Hudson, St Jude Children's Research Hospital, Memphis, TN; Eline van Dulmen-den Broeder, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Leontien C.M. Kremer, Academic Medical Center, Amsterdam, the Netherlands; Michael M. Hawkins, University of Birmingham, Birmingham, United Kingdom; Claudia E. Kuehni, University of Bern, Bern, Switzerland; and Jørgen H. Olsen, Danish Cancer Society Research Center, Copenhagen, Denmark.
Michael M HawkinsSmita Bhatia and Saro H. Armenian, City of Hope National Medical Center, Duarte, CA; Gregory T. Armstrong, Leslie L. Robison, and Melissa M. Hudson, St Jude Children's Research Hospital, Memphis, TN; Eline van Dulmen-den Broeder, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Leontien C.M. Kremer, Academic Medical Center, Amsterdam, the Netherlands; Michael M. Hawkins, University of Birmingham, Birmingham, United Kingdom; Claudia E. Kuehni, University of Bern, Bern, Switzerland; and Jørgen H. Olsen, Danish Cancer Society Research Center, Copenhagen, Denmark.
Leontien C M KremerSmita Bhatia and Saro H. Armenian, City of Hope National Medical Center, Duarte, CA; Gregory T. Armstrong, Leslie L. Robison, and Melissa M. Hudson, St Jude Children's Research Hospital, Memphis, TN; Eline van Dulmen-den Broeder, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Leontien C.M. Kremer, Academic Medical Center, Amsterdam, the Netherlands; Michael M. Hawkins, University of Birmingham, Birmingham, United Kingdom; Claudia E. Kuehni, University of Bern, Bern, Switzerland; and Jørgen H. Olsen, Danish Cancer Society Research Center, Copenhagen, Denmark.
Claudia E KuehniSmita Bhatia and Saro H. Armenian, City of Hope National Medical Center, Duarte, CA; Gregory T. Armstrong, Leslie L. Robison, and Melissa M. Hudson, St Jude Children's Research Hospital, Memphis, TN; Eline van Dulmen-den Broeder, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Leontien C.M. Kremer, Academic Medical Center, Amsterdam, the Netherlands; Michael M. Hawkins, University of Birmingham, Birmingham, United Kingdom; Claudia E. Kuehni, University of Bern, Bern, Switzerland; and Jørgen H. Olsen, Danish Cancer Society Research Center, Copenhagen, Denmark.
Jørgen H OlsenSmita Bhatia and Saro H. Armenian, City of Hope National Medical Center, Duarte, CA; Gregory T. Armstrong, Leslie L. Robison, and Melissa M. Hudson, St Jude Children's Research Hospital, Memphis, TN; Eline van Dulmen-den Broeder, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Leontien C.M. Kremer, Academic Medical Center, Amsterdam, the Netherlands; Michael M. Hawkins, University of Birmingham, Birmingham, United Kingdom; Claudia E. Kuehni, University of Bern, Bern, Switzerland; and Jørgen H. Olsen, Danish Cancer Society Research Center, Copenhagen, Denmark.
Leslie L RobisonSmita Bhatia and Saro H. Armenian, City of Hope National Medical Center, Duarte, CA; Gregory T. Armstrong, Leslie L. Robison, and Melissa M. Hudson, St Jude Children's Research Hospital, Memphis, TN; Eline van Dulmen-den Broeder, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Leontien C.M. Kremer, Academic Medical Center, Amsterdam, the Netherlands; Michael M. Hawkins, University of Birmingham, Birmingham, United Kingdom; Claudia E. Kuehni, University of Bern, Bern, Switzerland; and Jørgen H. Olsen, Danish Cancer Society Research Center, Copenhagen, Denmark.
Melissa M HudsonSmita Bhatia and Saro H. Armenian, City of Hope National Medical Center, Duarte, CA; Gregory T. Armstrong, Leslie L. Robison, and Melissa M. Hudson, St Jude Children's Research Hospital, Memphis, TN; Eline van Dulmen-den Broeder, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Leontien C.M. Kremer, Academic Medical Center, Amsterdam, the Netherlands; Michael M. Hawkins, University of Birmingham, Birmingham, United Kingdom; Claudia E. Kuehni, University of Bern, Bern, Switzerland; and Jørgen H. Olsen, Danish Cancer Society Research Center, Copenhagen, Denmark.

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
Towards a preventive cancer vaccine for children with constitutional mismatch repair deficiencyUG1CA189955 · NCI · PUBLIC HEALTH INSTITUTE · PI BRAD H POLLOCK, Michael E. Roth · 2014 to 2026
$62.5M
CHILDHOOD CANCER SURVIVOR STUDYU01CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROBISON, LESLIE L · 1993 to 1999
–
NCI NIH HHS CA21765NCI NIH HHS CA55727NCI NIH HHS P30 CA021765NCI NIH HHS U10 CA098543NCI NIH HHS U10CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U24 CA055727NCI NIH HHS UG1 CA189955
6 · The paper itself

Abstract

Survivors of childhood cancer carry a substantial burden of morbidity and are at increased risk for premature death. Furthermore, clear associations exist between specific therapeutic exposures and the risk for a variety of long-term complications. The entire landscape of health issues encountered for decades after successful completion of treatment is currently being explored in various collaborative research settings. These settings include large population-based or multi-institutional cohorts and single-institution studies. The ascertainment of outcomes has depended on self-reporting, linkage to registries, or clinical assessments. Survivorship research in the cooperative group setting, such as the Children's Oncology Group, has leveraged the clinical trials infrastructure to explore the molecular underpinnings of treatment-related adverse events, and to understand specific complications in the setting of randomized risk-reduction strategies. This review highlights the salient findings from these large collaborative initiatives, emphasizing the need for life-long follow-up of survivors of childhood cancer, and describing the development of several guidelines and efforts toward harmonization. Finally, the review reinforces the need to identify populations at highest risk, facilitating the development of risk prediction models that would allow for targeted interventions across the entire trajectory of survivorship.

Indexed as

Interdisciplinary CommunicationInternational CooperationMedical OncologyPediatricsAdolescentAge of OnsetChildCooperative BehaviorCost-Benefit AnalysisDiffusion of InnovationHealth Care CostsHealth StatusHumansNeoplasmsPractice Guidelines as TopicRisk Assessment

Identifiers

PMID26304891
PMCPMC4567704

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.