ArticleEnvironmental science and pollution research international2015
Effects of ambient PM2.5 on pathological injury, inflammation, oxidative stress, metabolic enzyme activity, and expression of c-fos and c-jun in lungs of rats.
Article in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Multi-omics of oxidative stress and particulate matter exposure: a systematic review.Respiratory research · 2026Pooled it
- Short-term exposure to air pollution and hospital admission for pneumonia: a systematic review and meta-analysis.Environmental health : a global access science source · 2021Pooled it
- Effects of prenatal exposure to NOEnvironmental science and pollution research international · 2020Pooled it
- Health risk and disease burden of daily hospitalizations for vaginitis due to air pollution: evidence from a heavily-polluted-city in China.BMC public health · 2025Article
- SIRT1-Mediated Epigenetic Protective Mechanisms of Phytosome-EncapsulatedInternational journal of molecular sciences · 2025Article
- Pathways to the Brain: Impact of Fine Particulate Matter Components on the Central Nervous System.Antioxidants (Basel, Switzerland) · 2025Review
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- Ambient Air Pollution Exposure and Outcomes in Patients Receiving Lung Transplant.JAMA network open · 2024Article
- Air Pollution and Parkinson Disease in a Population-Based Study.JAMA network open · 2024Article
- Evaluating exposure to vehicle pollutants using physics-informed immersive reality models.Royal Society open science · 2024Article
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- Attenuation of PMParticle and fibre toxicology · 2023Article
- An optimal medicinal and edible Chinese herbal formula attenuates particulate matter-induced lung injury through its anti-oxidative, anti-inflammatory and anti-apoptosis activities.Chinese herbal medicines · 2023Article
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- Associations of reproductive risk score and joint exposure to ambient air pollutants with chronic obstructive pulmonary disease: a cohort study in UK Biobank.Environmental health and preventive medicine · 2023Article
- Identification of differentially expressed genes and pathways in BEAS-2B cells upon long-term exposure to particulate matter (PMEnvironmental health and preventive medicine · 2023Article
- Exposure to particulate matter 2.5 leading to lung microbiome disorder and the alleviation effect ofInternational journal of occupational medicine and environmental health · 2022Article
- Biomass Smoke Exposure and Atopy among Young Children in the Western Highlands of Guatemala: A Prospective Cohort Study.International journal of environmental research and public health · 2022Article
- Preventive Effect of Epigallocatechin Gallate, the Main Component of Green Tea, on Acute Lung Injury Caused by Air Pollutants.Biomolecules · 2022Article
- Diesel Exhaust Particles Impair Therapeutic Effect of Human Wharton's Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis through ROS/ERK/cFos Signaling Pathway.International journal of stem cells · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fine particulate matter (PM2.5) exposure is associated with morbidity and mortality induced by respiratory diseases and increases the lung cancer risk. However, the mechanisms therein involved are not yet fully clarified. In this study, the PM2.5 suspensions at different dosages (0.375, 1.5, 6.0, and 24.0 mg/kg body weight) were respectively given to rats by the intratracheal instillation. The results showed that PM2.5 exposure induced inflammatory cell infiltration and hyperemia in the lung tissues and increased the inflammatory cell numbers in bronchoalveolar lavage fluid. Furthermore, PM2.5 significantly elevated the levels of pro-inflammatory mediators including tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-1β, and intercellular adhesion molecule 1 (ICAM-1) and the expression of c-fos and c-jun in rat lungs exposed to higher dose of PM2.5. These changes were accompanied by decreases of activities of superoxide dismutase and increases of levels of malondialdehyde, inducible nitric oxide synthase, nitric oxide, cytochrome P450s, and glutathione S-transferase. The results implicated that acute exposure to PM2.5 induced pathologically pulmonary changes, unchained inflammatory and oxidative stress processes, activated metabolic enzyme activity, and enhanced proto-oncogene expression, which might be one of the possible mechanisms by which PM2.5 pollution induces lung injury and may be the important determinants for the susceptibility to respiratory diseases.
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