Evidence map›Paper›PMID 26304661›Full record

ArticleNeurocase2016

Early-onset Alzheimer's disease versus frontotemporal dementia: resolution with genetic diagnoses?

Sharon J Sha, Anna M Khazenzon, Pia M Ghosh, Katherine P Rankin, Mochtar Pribadi, Giovanni Coppola, Daniel H Geschwind, Gil D Rabinovici, Bruce L Miller, Suzee E Lee

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocase, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Sharon J Shaa Department of Neurology and Neurological Sciences , Stanford University , Stanford , CA , USA.
Anna M Khazenzonb Department of Neurology, Memory and Aging Center , University of California , San Francisco , CA , USA.
Pia M Ghoshb Department of Neurology, Memory and Aging Center , University of California , San Francisco , CA , USA.
Katherine P Rankinb Department of Neurology, Memory and Aging Center , University of California , San Francisco , CA , USA.
Mochtar Pribadid Departments of Psychiatry and Neurology , Semel Institute for Neuroscience and Human Behavior, University of California , Los Angeles , CA , USA.
Giovanni Coppolad Departments of Psychiatry and Neurology , Semel Institute for Neuroscience and Human Behavior, University of California , Los Angeles , CA , USA.
Daniel H Geschwindd Departments of Psychiatry and Neurology , Semel Institute for Neuroscience and Human Behavior, University of California , Los Angeles , CA , USA.
Gil D Rabinovicib Department of Neurology, Memory and Aging Center , University of California , San Francisco , CA , USA.
Bruce L Millerb Department of Neurology, Memory and Aging Center , University of California , San Francisco , CA , USA.
Suzee E Leeb Department of Neurology, Memory and Aging Center , University of California , San Francisco , CA , USA.
University Memory and Aging Center · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USStanford University · USUniversity of California, Berkeley · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Multidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4M
Attention and Semantic Evaluation as Predictors of Empathy in Healthy Aging and Frontotemporal DementiaRF1AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2019 to 2019
$4.0M
Measuring Altered Social Behavior in Neurodegenerative DiseaseR01AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2008 to 2018
$3.6M
Detecting presymptomatic disease in inherited frontotemporal dementiaK23AG039414 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, SUZEE EURIE · 2011 to 2015
$762k
NIA NIH HHS K23 AG039414NIA NIH HHS P01 AG019724NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG029577NIA NIH HHS RF1 AG029577NIA NIH HHS T32 AG023481
6 · The paper itself

Abstract

We report a diagnostically challenging case of a 64-year-old man with a history of remote head trauma who developed mild behavioral changes and dyscalculia. He was diagnosed with clinical Alzheimer's disease (AD), with additional features consistent with behavioral variant frontotemporal dementia. Structural magnetic resonance imaging revealed atrophy in bilateral frontal and parietal cortices and hippocampi on visual inspection and left frontal pole and bilateral anterior temporal encephalomalacia, suspected to be due to head trauma. Consistent with the diagnosis of Alzheimer's pathology, positron emission tomography (PET) with Pittsburgh compound B suggested the presence of beta-amyloid. Fluorodeoxyglucose PET demonstrated hypometabolism in bilateral frontal and temporoparietal cortices. Voxel-based morphometry showed atrophy predominant in ventral frontal regions (bilateral orbitofrontal cortex, pregenual anterior cingulate/medial superior frontal gyrus), bilateral mid cingulate, bilateral lateral temporal cortex, and posterior insula. Bilateral caudate, thalamus, hippocampi, and cerebellum were prominently atrophied. Unexpectedly, a pathologic hexanucleotide repeat expansion in C9ORF72 was identified in this patient. This report underscores the clinical variability in C9ORF72 expansion carriers and the need to consider mixed pathologies, particularly when imaging studies are inconsistent with a single syndrome or pathology.

Indexed as

Alzheimer DiseaseFrontotemporal DementiaAniline CompoundsApolipoproteins EBrainC9orf72 ProteinCarbon IsotopesEmotionsFluorodeoxyglucose F18HumansMagnetic Resonance ImagingMaleMemoryMiddle AgedMutationNeuropsychological Tests2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAniline CompoundsApolipoproteins EC9orf72 ProteinC9orf72 protein, humanCarbon IsotopesFluorodeoxyglucose F18ProteinsThiazolesAlzheimer’s diseaseFrontotemporal dementia

Identifiers

PMID26304661
PMCPMC4733403
OpenAlexW1150461579

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.