ArticleWorld journal of surgery2015
Prognostic Impact of Distribution of Lymph Node Metastases in Stage III Colon Cancer.
Article in World journal of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Definition and reporting of lymphadenectomy and complete mesocolic excision for radical right colectomy: a systematic review.Surgical endoscopy · 2023Pooled it
- Prognosis of Patients With Colorectal Cancer and Apical Lymph Node Metastasis at the Inferior Mesenteric Artery: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- A Randomized Phase III Trial of Complete Mesocolic Excision Compared with Conventional Surgery for Right Colon Cancer: Interim Analysis of a Nationwide Multicenter Study of the Italian Society of Surgical Oncology Colorectal Cancer Network (CoME-in trial).Annals of surgical oncology · 2024Trial
- Complete Mesocolic Excision for Colon Cancer: Insight into Potential Mechanisms of Oncologic Benefit.Cancers · 2025Review
- Prognostic value of lymph node distribution after laparoscopic colectomy with Japanese D3 dissection.Langenbeck's archives of surgery · 2024Article
- Size and number of lymph nodes were risk factors of recurrence in stage II colorectal cancer.BMC cancer · 2023Article
- Prognostic Impact of Main Lymph Node Metastasis in Patients with Colon Cancer.World journal of surgery · 2023Article
- Complete mesocolic excision and central vascular ligation in colorectal cancer in the era of minimally invasive surgery.World journal of clinical cases · 2021Review
- Central vascular ligation and mesentery based abdominal surgery.Discover oncology · 2021Review
- Educational system for acquiring appropriate laparoscopic colorectal surgical skills: analysis in a Japanese high-volume cancer center.Surgical endoscopy · 2021Article
- Pathological features of lymph nodes around inferior mesenteric artery in rectal cancer: a retrospective study.World journal of surgical oncology · 2021Article
- Improved oncologic outcomes with increase of laparoscopic surgery in modified complete mesocolic excision with D3 lymph node dissection for T3/4a colon cancer: results of 1191 consecutive patients during a 10-year period: a retrospective cohort study.International journal of clinical oncology · 2021Article
- Concept of Complete Mesocolic Excision and the Role of Computed Tomography Imaging.Seminars in roentgenology · 2021Article
- Prognostic Value of the Distribution of Lymph Node Metastasis in Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiotherapy.Frontiers in surgery · 2021Article
- Complete mesocolic excision and central vascular ligation for right colon cancer: an introduction for abdominal radiologists.Abdominal radiology (New York) · 2019Review
- Clinical Implications of Lymph Node Metastasis in Colorectal Cancer: Current Status and Future Perspectives.Annals of coloproctology · 2019Review
- Application of ultrasonography to high-tie and low-tie vascular ligation of the inferior mesenteric artery in laparoscopic colorectal cancer surgery: technical notes.Surgical endoscopy · 2019Article
- Anatomy of the right colic vein and pancreaticoduodenal branches: a surgical landmark for laparoscopic complete mesocolic excision of the right colon.Surgical and radiologic anatomy : SRA · 2018Article
- The distribution of lymph node metastases and their size in colon cancer.Langenbeck's archives of surgery · 2017Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComplete mesocolic excision (CME) with central vascular ligation (CVL) is a well-known concept in colon cancer surgery. However, data on the oncological benefits of CVL are scarce. The objective of this study was to evaluate the prognostic significance of the distribution of lymph node metastases (LND) in patients with stage III colon cancer who underwent CME with CVL.
methodsIn total, 446 consecutive patients who underwent curative resection for stage III colon cancer from 2005 to 2011 were analyzed. Patients were classified as having LND1 (metastases in pericolic nodes), LND2 (metastases in intermediate nodes), or LND3 (metastases in main nodes). Survival outcomes were compared among the three groups.
resultsLND1, LND2, and LND3 were identified in 299 (67.0 %), 122 (27.4 %), and 25 (5.6 %) patients, respectively. The 5-year overall survival and relapse-free survival (RFS) of all patients were 86.7 and 76.2 %, respectively. The 5-year RFS of patients with LND1, LND2, and LND3 were 82.8, 65.4, and 52.0 %, respectively (p < 0.0001). Multivariate analysis showed that LND2 was an independent prognostic factor for RFS (p = 0.0185), although the significance of LND3 was marginal (p = 0.0621). Among patients with pN1, the 5-year RFS of patients with LND1 and LND2+3 were significantly different (84.4 vs. 71.5 %, respectively, p = 0.0102), and similar tendency was found between patients with pN2-LND1 and pN2-LND2+3 (72.6 vs. 53.1 %, p = 0.0428).
conclusionThe high 5-year survival rates of patients with stage III colon cancer, even those with LND2 and LND3, would justify CVL as the standard procedure for advanced colon cancer.
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