ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
Distinctive expression pattern of interleukin-17 cytokine family members in colorectal cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Variable roles of interleukin-17F in different cancers.BMC cancer · 2022Pooled it
- Interleukin-17F suppressed colon cancer by enhancing caspase 4 mediated pyroptosis of endothelial cells.Scientific reports · 2024Article
- Article
- Interleukin 17 in early invasive breast cancer.Frontiers in oncology · 2023Article
- Review
- Emerging roles for IL-25 and IL-33 in colorectal cancer tumorigenesis.Frontiers in immunology · 2022Review
- Integrin-Linked Kinase Expression Characterizes the Immunosuppressive Tumor Microenvironment in Colorectal Cancer and Regulates PD-L1 Expression and Immune Cell Cytotoxicity.Frontiers in oncology · 2022Article
- Interleukin-25: New perspective and state-of-the-art in cancer prognosis and treatment approaches.Cancer medicine · 2021Review
- The effect of interleukin-17F on vasculogenic mimicry in oral tongue squamous cell carcinoma.Cancer science · 2021Article
- Immunohistochemical expression of interleukin-17 and hormonal receptors in benign and malignant breast lesions.BMC research notes · 2020Article
- Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer.World journal of gastroenterology · 2020Observational
- Targeting the interleukin-17 immune axis for cancer immunotherapy.The Journal of experimental medicine · 2020Review
- Much More Than IL-17A: Cytokines of the IL-17 Family Between Microbiota and Cancer.Frontiers in immunology · 2020Review
- The Emerging Role of the IL-17B/IL-17RB Pathway in Cancer.Frontiers in immunology · 2020Review
- Article
- Interleukin-17 promotes the development of cisplatin resistance in colorectal cancer.Oncology letters · 2019Article
- Helper Innate Lymphoid Cells in Human Tumors: A Double-Edged Sword?Frontiers in immunology · 2019Review
- Genetic and molecular origins of colorectal Cancer among the Iranians: an update.Diagnostic pathology · 2018Review
- A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family MembersFrontiers in immunology · 2018Article
- Targeting the Tumor Microenvironment: The Protumor Effects of IL-17 Related to Cancer Type.International journal of molecular sciences · 2016Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is one of the most common cancers in both genders. Even though interleukin (IL)-17A was shown to play an important role in intestinal tumourigenesis and CRC, other IL-17 family members were not studied well. We therefore studied the expression of IL-17 cytokine family members in CRC. Ten healthy colons and ten CRC mucosa were immunostained for IL-17B, IL-17C, IL-17E, and IL-17F, and their receptors IL-17RA, IL-17RB, and IL-17RC. Double immunofluorescence staining of the CRC mucosa was done for IL-17B with markers of neutrophils, endothelial cells, macrophages, T cells, mast cells, or fibroblasts. While IL-17B was increased in CRC with a strong presence both in the epithelial and stromal compartments, IL-17C showed different expression depending on the grade of differentiation and IL-17E remained unchanged. In contrast, IL-17F was decreased in CRC compared to healthy control. Colon epithelial cells stained positive for IL-17RA, IL-17RB, and IL-17RC in both healthy control and CRC. Neutrophils were the main source of IL-17B in the stroma. IL-17 family members demonstrated distinct expression patterns in CRC, suggesting a differential role exerted by each member in colon carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.