Evidence map›Paper›PMID 26304100›Full record

ArticleJournal of assisted reproduction and genetics2015

Contribution of TIMP3 polymorphisms to the development of preeclampsia in Han Chinese women.

Changlong Guo, Xiaofang Cao, Qidi Wang, Guangyu Wang, Lisha An, Meng Du, Yue Qiu, Ying Yang, Hui Li, Yuting Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Changlong GuoNational Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
Xiaofang CaoNational Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
Qidi WangNational Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
Guangyu WangNational Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
Lisha AnNational Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
Meng DuNational Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
Yue QiuNational Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
Ying YangNational Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
Hui LiDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Yuting WangDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Shuo WangDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Xingyu WangNational Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China. xingyuwang@yahoo.com.
Xu MaNational Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China. xumagroup@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to investigate whether polymorphisms in the tissue inhibitor of metalloproteinase 3 gene (TIMP3) are associated with the risk of preeclampsia (PE) in Han Chinese women.

methodsNine single TIMP3 tag-single nucleotide polymorphisms were selected by Haploview and genotyped using the Sequenom method in 181 preeclamptic and 203 healthy pregnant women from eastern China.

resultsThe allele frequencies of the tag-single nucleotide polymorphisms were not significantly different between groups (P > 0.05). However, the genotype distribution of rs135025 was shown to differ between the multigravidity PE subgroup (>3) and controls under additive (P = 0.018) and recessive models (P = 0.008), while the genotype distribution of rs80272 differed significantly between the severe PE subgroup and controls under additive (P = 0.014) and dominant models (P = 0.041). Moreover, the H2 haplotype (A-C-G-T-A-A-G-C-G) was found to be associated with the risk of PE (P = 0.035).

conclusionsGenotypes of rs135025 and rs80272 in TIMP3 may therefore influence susceptibility to PE, and pregnant women carrying the H2 haplotype might be more prone to developing PE.

Indexed as

Polymorphism, Single NucleotideAdultAsian PeopleCase-Control StudiesChinaFemaleGene FrequencyGenetic Predisposition to DiseaseHaplotypesHumansMaternal AgePregnancyTissue Inhibitor of Metalloproteinase-3TIMP3 protein, humanTissue Inhibitor of Metalloproteinase-3Genetic polymorphismHaplotype analysisPreeclampsiaTissue inhibitors of matrix metalloproteinases 3

Identifiers

PMID26304100
PMCPMC4615926

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.