Evidence map›Paper›PMID 26304036›Full record

ArticleStem cells translational medicine2015

Perivascular Mesenchymal Stem Cells From the Adult Human Brain Harbor No Instrinsic Neuroectodermal but High Mesodermal Differentiation Potential.

Xenia Lojewski, Sumitra Srimasorn, Juliane Rauh, Silvan Francke, Manja Wobus, Verdon Taylor, Marcos J Araúzo-Bravo, Susanne Hallmeyer-Elgner, Matthias Kirsch, Sigrid Schwarz and 3 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Five Decades Later, Are Mesenchymal Stem Cells Still Relevant?Frontiers in bioengineering and biotechnology · 2020
    Review
  9. Review
  10. Article
  11. Optimized Clump Culture Methods for Adult Human Multipotent Neural Cells.International journal of molecular sciences · 2018
    Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Xenia LojewskiDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.
Sumitra SrimasornDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.
Juliane RauhDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.
Silvan FranckeDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.
Manja WobusDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.
Verdon TaylorDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.
Marcos J Araúzo-BravoDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.
Susanne Hallmeyer-ElgnerDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.
Matthias KirschDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.
Sigrid SchwarzDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.
Johannes SchwarzDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.
Alexander StorchDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany.
Andreas HermannDivision of Neurodegenerative Diseases, Department of Neurology, University Center for Orthopaedics and Trauma Surgery and Center for Translational Bone, Joint and Soft Tissue Research, Department of Medicine I, Faculty of Medicine, and Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany; Department of Biomedicine, University of Basel, Basel, Switzerland; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department for Translational Neurodegeneration, Technical University of Munich, German Centre for Neurodegenerative Diseases, Munich, Germany; Geriatric Hospital Haag, Haag, Germany; Department of Neurology, Technical University of Munich, Munich, Germany; Center for Regenerative Therapies Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases Dresden, Dresden, Germany andreas.hermann@uniklinikum-dresden.de.
TU Dresden · DEGerman Center for Neurodegenerative Diseases · DEBiogipuzkoa Health Research Institute · ESIkerbasque · ESTechnical University of Munich · DEUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledBrain perivascular cells have recently been identified as a novel mesodermal cell type in the human brain. These cells reside in the perivascular niche and were shown to have mesodermal and, to a lesser extent, tissue-specific differentiation potential. Mesenchymal stem cells (MSCs) are widely proposed for use in cell therapy in many neurological disorders; therefore, it is of importance to better understand the "intrinsic" MSC population of the human brain. We systematically characterized adult human brain-derived pericytes during in vitro expansion and differentiation and compared these cells with fetal and adult human brain-derived neural stem cells (NSCs) and adult human bone marrow-derived MSCs. We found that adult human brain pericytes, which can be isolated from the hippocampus and from subcortical white matter, are-in contrast to adult human NSCs-easily expandable in monolayer cultures and show many similarities to human bone marrow-derived MSCs both regarding both surface marker expression and after whole transcriptome profile. Human brain pericytes showed a negligible propensity for neuroectodermal differentiation under various differentiation conditions but efficiently generated mesodermal progeny. Consequently, human brain pericytes resemble bone marrow-derived MSCs and might be very interesting for possible autologous and endogenous stem cell-based treatment strategies and cell therapeutic approaches for treating neurological diseases. SIGNIFICANCE: Perivascular mesenchymal stem cells (MSCs) recently gained significant interest because of their appearance in many tissues including the human brain. MSCs were often reported as being beneficial after transplantation in the central nervous system in different neurological diseases; therefore, adult brain perivascular cells derived from human neural tissue were systematically characterized concerning neural stem cell and MSC marker expression, transcriptomics, and mesodermal and inherent neuroectodermal differentiation potential in vitro and in vivo after in utero transplantation. This study showed the lack of an innate neuronal but high mesodermal differentiation potential. Because of their relationship to mesenchymal stem cells, these adult brain perivascular mesodermal cells are of great interest for possible autologous therapeutic use.

Indexed as

AdultAnimalsBrainCell DifferentiationCell LineageChildFemaleFetal Stem CellsGene Expression ProfilingGraft SurvivalHeterograftsHippocampusHumansMaleMesenchymal Stem CellsMesodermBrain pericytesBrain perivascular cellsHippocampusMonolayer cultureNeural progenitor cellsWhite matter

Identifiers

PMID26304036
PMCPMC4572903
OpenAlexW2258652940

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.