Evidence map›Paper›PMID 26303948›Full record

ArticleEMBO reports2015

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network.

Hongbin Zhang, Meiping Guan, Kristy L Townsend, Tian Lian Huang, Ding An, Xu Yan, Ruidan Xue, Tim J Schulz, Jonathon Winnay, Marcelo Mori and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed.

  1. Review
  2. Research progress on blood therapy for anti-aging.Journal of advanced research · 2026
    Review
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  6. Review
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  14. Article
  15. Review
  16. Review
  17. Article
  18. Pulling the trigger: Noncoding RNAs in white adipose tissue browning.Reviews in endocrine & metabolic disorders · 2024
    Review
  19. Review
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hongbin ZhangSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark hongbin@sund.ku.dk yu-hua.tseng@joslin.harvard.edu.
Meiping GuanSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Kristy L TownsendSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Tian Lian HuangSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Ding AnSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Xu YanSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Ruidan XueSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Tim J SchulzSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Adipocyte Development Research Group, German Institute of Human Nutrition, Potsdam, Germany.
Jonathon WinnaySection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Marcelo MoriSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Department of Biophysics, Federal University of Sao Paulo, Sao Paulo, Brazil.
Michael F HirshmanSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Karsten KristiansenDepartment of Biology, University of Copenhagen, Copenhagen, Denmark.
John S TsangSystems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases (NIAID) and Trans-NIH Center for Human Immunology, National Institutes of Health, Bethesda, MD, USA.
Andrew P WhiteDepartment of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Aaron M CypessSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Laurie J GoodyearSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Yu-Hua TsengSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA hongbin@sund.ku.dk yu-hua.tseng@joslin.harvard.edu.

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Integrative analysis and modeling of human immune responses and pathologiesZIAAI001152 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TSANG, JOHN · 2011 to 2022
$14.1M
TRAINING IN DIABETES AND METABOLISMT32DK007260 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 1986 to 2026
$13.6M
Role of BMPs in Adipogenesis, Mitochondrial Function and Energy MetabolismR01DK077097 · NIDDK · JOSLIN DIABETES CENTER · PI TSENG, YU-HUA · 2007 to 2019
$5.6M
EXERCISE AND SKELETAL MUSCLE SIGNALING MECHANISMSR01AR042238 · NIAMS · JOSLIN DIABETES CENTER · PI GOODYEAR, LAURIE J · 1997 to 2013
$4.2M
Systems biology of macrophage activation and plasticity - from single cells to information propagation in networksZIAAI001143 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TSANG, JOHN · 2011 to 2020
$4.0M
The Molecular, Cellular, and Genetic characterization of Human Adipose Tissue and its Role in MetabolismZIADK075112 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CYPESS, AARON · 2015 to 2025
$2.8M
Mechanisms Underlying Adipose Tissue ThermogenesisZIADK075115 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CYPESS, AARON · 2015 to 2025
$1.8M
BMP7 and the regulation of central and peripheral energy balanceF32DK091996 · NIDDK · JOSLIN DIABETES CENTER · PI TOWNSEND, KRISTY L · 2011 to 2012
$109k
Intramural NIH HHSNIAMS NIH HHS R01 AR042238NIAMS NIH HHS R01AR042238NIDDK NIH HHS F32 DK091996NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK077097NIDDK NIH HHS T32 DK007260NIDDK NIH HHS T32 DK007260-33
6 · The paper itself

Abstract

Brown adipose tissue (BAT) dissipates chemical energy as heat and can counteract obesity. MicroRNAs are emerging as key regulators in development and disease. Combining microRNA and mRNA microarray profiling followed by bioinformatic analyses, we identified miR-455 as a new regulator of brown adipogenesis. miR-455 exhibits a BAT-specific expression pattern and is induced by cold and the browning inducer BMP7. In vitro gain- and loss-of-function studies show that miR-455 regulates brown adipocyte differentiation and thermogenesis. Adipose-specific miR-455 transgenic mice display marked browning of subcutaneous white fat upon cold exposure. miR-455 activates AMPKα1 by targeting HIF1an, and AMPK promotes the brown adipogenic program and mitochondrial biogenesis. Concomitantly, miR-455 also targets the adipogenic suppressors Runx1t1 and Necdin, initiating adipogenic differentiation. Taken together, the data reveal a novel microRNA-regulated signaling network that controls brown adipogenesis and may be a potential therapeutic target for human metabolic disorders.

Indexed as

Signal TransductionAdipocytes, BrownAdipogenesisAdipose Tissue, WhiteAMP-Activated Protein KinasesAnimalsCell DifferentiationCells, CulturedCold TemperatureHumansMiceMice, TransgenicMicroRNAsMixed Function OxygenasesNerve Tissue ProteinsNuclear ProteinsAMP-Activated Protein Kinasesfactor inhibiting hypoxia-inducible factor 1, mouseHIF1AN protein, humanMicroRNAsMIRN455 microRNA, humanMIRN455 microRNA, mouseMixed Function OxygenasesnecdinNerve Tissue ProteinsNuclear ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseRepressor ProteinsTranscription Factorsbrown adipogenesisdifferentiationmetabolismmicroRNAUCP1

Identifiers

PMID26303948
PMCPMC4766451

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.