ArticleBMC microbiology2015
Acquisition of the lac operon by Salmonella enterica.
Article in BMC microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Serological investigation and isolation of Salmonella abortus equi in horses in Xinjiang.BMC veterinary research · 2024Article
- Plasmid-encoded lactose metabolism and mobilized colistin resistance (Microbial genomics · 2023Article
- Pet Reptiles in Poland as a Potential Source of Transmission ofPathogens (Basel, Switzerland) · 2022Article
- Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya.PLoS neglected tropical diseases · 2021Article
- HybridFrontiers in microbiology · 2021Article
- Detection and Molecular Identification ofPathogens (Basel, Switzerland) · 2019Article
- The diversity, evolution and ecology of Salmonella in venomous snakes.PLoS neglected tropical diseases · 2019Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundClassical bacteriological characteristics of Salmonella enterica indicate that the members of this species are unable to utilize lactose as a carbon source. However, lactose-fermenting (Lac+) strains of several Salmonella serovars have been isolated from different foodborne outbreaks as well as different geographical regions worldwide. In the present study, we sequenced the genomes of 13 Lac + S. enterica isolates and characterized the lac region, comparing it to the lac region in other enteric bacterial species.
resultsGenetic analysis of the lac operons in the S. enterica genomes revealed that they all contain intact lacI, lacZ, and lacY genes. However, lacA was truncated in all of the S. enterica subsp. enterica isolates, encoding a 56 amino acid peptide rather than the full length 220 amino acid LacA protein. Molecular analyses of the 13 isolates revealed that the lac operon resided on a plasmid in some strains and in others was integrated into the bacterial chromosome. In most cases, an insertion sequence flanked at least one end of the operon. Interestingly, the S. enterica Montevideo and S. enterica Senftenberg isolates were found to harbor a plasmid with a high degree of sequence similarity to a plasmid from Klebsiella pneumoniae strain NK29 that also harbors the lac operon. In addition, two S. enterica Tennessee isolates carried two copies of the lac operon. Phylogenetic analysis based on lacIZY gene sequences determines distinct clusters, and reveals a greater correlation between lacIZY sequence and flanking organization than with either bacterial species or genomic location.
conclusionsOur results indicate that the lac region is highly mobile among Enterobacteriaceae and demonstrate that the Lac + S. enterica subsp. enterica serovars acquired the lac region through parallel events. The acquisition of the lac operon by several S. enterica serovars may be indicative of environmental adaptation by these bacteria.
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