Evidence map›Paper›PMID 26303936›Full record

Trial reportSchizophrenia bulletin2016

Effects of Fronto-Temporal Transcranial Direct Current Stimulation on Auditory Verbal Hallucinations and Resting-State Functional Connectivity of the Left Temporo-Parietal Junction in Patients With Schizophrenia.

Marine Mondino, Renaud Jardri, Marie-Françoise Suaud-Chagny, Mohamed Saoud, Emmanuel Poulet, Jérôme Brunelin

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 8 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 8 syntheses or guidelines pooled it, 210 citations in OpenAlex.

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  14. Randomized trial of transcranial alternating current stimulation for treatment of auditory hallucinations in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2018
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Marine MondinoEA4615, Université de Lyon & CH Le Vinatier, F-69678 Bron, France;
Renaud JardriLaboratoire de Sciences Cognitives & Affectives (SCA-Lab), UMR CNRS 9193, Université de Lille & CURE, Hôpital Fontan, CHRU de Lille, F-59000, Lille, France.
Marie-Françoise Suaud-ChagnyEA4615, Université de Lyon & CH Le Vinatier, F-69678 Bron, France;
Mohamed SaoudEA4615, Université de Lyon & CH Le Vinatier, F-69678 Bron, France;
Emmanuel PouletEA4615, Université de Lyon & CH Le Vinatier, F-69678 Bron, France;
Jérôme BrunelinEA4615, Université de Lyon & CH Le Vinatier, F-69678 Bron, France; jerome.brunelin@ch-le-vinatier.fr.
Centre Hospitalier Le Vinatier · FRSciences Cognitives et Sciences Affectives · FRUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Auditory verbal hallucinations (AVH) in patients with schizophrenia are associated with abnormal hyperactivity in the left temporo-parietal junction (TPJ) and abnormal connectivity between frontal and temporal areas. Recent findings suggest that fronto-temporal transcranial Direct Current stimulation (tDCS) with the cathode placed over the left TPJ and the anode over the left prefrontal cortex can alleviate treatment-resistant AVH in patients with schizophrenia. However, brain correlates of the AVH reduction are unclear. Here, we investigated the effect of tDCS on the resting-state functional connectivity (rs-FC) of the left TPJ. Twenty-three patients with schizophrenia and treatment-resistant AVH were randomly allocated to receive 10 sessions of active (2 mA, 20 min) or sham tDCS (2 sessions/d for 5 d). We compared the rs-FC of the left TPJ between patients before and after they received active or sham tDCS. Relative to sham tDCS, active tDCS significantly reduced AVH as well as the negative symptoms. Active tDCS also reduced rs-FC of the left TPJ with the left anterior insula and the right inferior frontal gyrus and increased rs-FC of the left TPJ with the left angular gyrus, the left dorsolateral prefrontal cortex and the precuneus. The reduction of AVH severity was correlated with the reduction of the rs-FC between the left TPJ and the left anterior insula. These findings suggest that the reduction of AVH induced by tDCS is associated with a modulation of the rs-FC within an AVH-related brain network, including brain areas involved in inner speech production and monitoring.

Indexed as

AdultDouble-Blind MethodFemaleFunctional NeuroimagingHallucinationsHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetParietal LobeSchizophreniaSpeech PerceptionTemporal LobeTranscranial Direct Current StimulationTreatment Outcomebrain stimulationfMRIresting statetemporal cortex

Identifiers

PMID26303936
PMCPMC4753593
OpenAlexW2252719872

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.