Evidence map›Paper›PMID 26303870›Full record

ArticleMetabolism: clinical and experimental2015

Cord blood irisin levels are positively correlated with birth weight in newborn infants.

Kyoung Eun Joung, Kyung-Hee Park, Andreas Filippaios, Fadime Dincer, Helen Christou, Christos S Mantzoros

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism: clinical and experimental, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Kyoung Eun JoungDivision of Newborn Medicine, Boston Children's Hospital, 300 Brookline Ave, Boston, MA, 02115, USA; Department of Pediatrics, Division of Neonatology, Goryeb Children's Hospital, 100 Madison Ave, Morristown, NJ, 07960, USA; Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, 300 Brookline Ave, Boston, MA, 02215, USA; Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA.
Kyung-Hee ParkDivision of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, 300 Brookline Ave, Boston, MA, 02215, USA; Department of Family Medicine, Hallym University Sacred Heart Hospital, Hallym University, Gyeonggi-do, 431-070, Republic of Korea.
Andreas FilippaiosDivision of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, 300 Brookline Ave, Boston, MA, 02215, USA.
Fadime DincerDivision of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, 300 Brookline Ave, Boston, MA, 02215, USA.
Helen ChristouDivision of Newborn Medicine, Boston Children's Hospital, 300 Brookline Ave, Boston, MA, 02115, USA; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, 75 Francis St, Boston, MA, 02115, USA; Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA. Electronic address: hchristou@partners.org.
Christos S MantzorosDivision of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, 300 Brookline Ave, Boston, MA, 02215, USA; Section of Endocrinology, Division of Endocrinology, Boston VA Healthcare System, Jamaica Plain, MA, 02130, USA; Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA.
Beth Israel Deaconess Medical Center · USBoston Children's Hospital · USBrigham and Women's Hospital · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
NCRR NIH HHS UL1 RR025758NCRR NIH HHS UL1RR025758
6 · The paper itself

Abstract

backgroundIrisin is a novel myokine, secreted from skeletal muscle after exercise. Irisin mediates exercise-related energy expenditure by turning white adipose tissue (WAT) into brown adipose tissue (BAT). Thus, irisin is considered as a potential biomarker for obesity and metabolic syndrome. Infants born small for gestational age (SGA) have increased risk for metabolic syndrome. However, the physiologic role of irisin in neonates remains to be studied.

objectiveTo evaluate the association of umbilical cord blood irisin levels with gestational age and birth weight categories in neonates.

methodsA cross-sectional study of 341 newborns, from 26 to 41weeks' gestation. We collected umbilical cord blood and analyzed plasma for irisin by ELISA.

resultsPlasma irisin levels were positively correlated with gestational age (r=0.21, p<0.001), and birth weight Z-score (r=0.18, p<0.001). SGA infants had significantly lower irisin (median [interquartile range] 55.38 [46.56-65.72]ng/mL) compared to appropriate for gestational age infants (64.41 [53.87-76.76]ng/mL) and large for gestational age infants (68.70 [54.78-79.09]ng/mL, p<0.01). The association between SGA and lower irisin remained significant in multivariate analysis independent of gestational age, maternal age, maternal BMI, and gestational diabetes (p=0.03). In singleton infants, irisin was also significantly negatively associated with maternal preeclampsia (p=0.01).

conclusionsOur results support the notion that irisin may have a physiologic role in neonates. We speculate that decreased levels of irisin in SGA infants may contribute to the development of catch-up growth and metabolic syndrome later in life.

Indexed as

Birth WeightFetal DevelopmentAdultBiomarkersFemaleFetal BloodFibronectinsHumansInfant, NewbornInsulinMaleBiomarkersFibronectinsFNDC5 protein, humanInsulinBirth weightCord bloodIrisinNewborn

Identifiers

PMID26303870
PMCPMC5348079
OpenAlexW2122533571

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.