Evidence map›Paper›PMID 26303804›Full record

ArticleAntimicrobial agents and chemotherapy2015

Sensititre MycoTB plate compared to Bactec MGIT 960 for first- and second-line antituberculosis drug susceptibility testing in Tanzania: a call to operationalize MICs.

Scott K Heysell, Suporn Pholwat, Stellah G Mpagama, Saumu J Pazia, Happy Kumburu, Norah Ndusilo, Jean Gratz, Eric R Houpt, Gibson S Kibiki

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  5. Article
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  7. Article
  8. Molecular Analysis of Anti-Tuberculosis Drug Resistance ofAntibiotics (Basel, Switzerland) · 2023
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  9. MarR-Dependent Transcriptional Regulation ofAntimicrobial agents and chemotherapy · 2023
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  15. Article
  16. Article
  17. Article
  18. Management of patients with multidrug-resistant tuberculosis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2019
    Review
  19. Open forum infectious diseases · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Scott K HeysellDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA skh8r@virginia.edu.
Suporn PholwatDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Stellah G MpagamaKibong'oto Infectious Diseases Hospital, Sanya Juu, Tanzania.
Saumu J PaziaKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Happy KumburuKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Norah NdusiloKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Jean GratzDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Eric R HouptDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Gibson S KibikiKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Kilimanjaro Christian Medical Centre · TZUniversity of Virginia · US

Funding

Tuberculosis Second Line Drug Susceptibility ChipR01AI093358 · NIAID · UNIVERSITY OF VIRGINIA · PI HOUPT, ERIC R · 2011 to 2015
$4.0M
Global Infectious Disease Research Training Program AwardD43TW008270 · FIC · UNIVERSITY OF VIRGINIA · PI HOUPT, ERIC R · 2010 to 2014
$735k
Clinical Impact of Anti-TB Drug Levels and M. Tuberculosis SusceptibilityK23AI099019 · NIAID · UNIVERSITY OF VIRGINIA · PI HEYSELL, SCOTT K · 2012 to 2016
$649k
FIC NIH HHS D43 TW008270NIAID NIH HHS K23 AI099019NIAID NIH HHS K23AI099019NIAID NIH HHS R01 AI093358NIAID NIH HHS R01AI093358
6 · The paper itself

Abstract

MIC testing for Mycobacterium tuberculosis is now commercially available. Drug susceptibility testing by the MycoTB MIC plate has not been directly compared to that by the Bactec MGIT 960. We describe a case of extensively drug-resistant tuberculosis (XDR-TB) in Tanzania where initial MIC testing may have prevented acquired resistance. From testing on archived isolates, the accuracy with the MycoTB plate was >90% for important first- and second-line drugs compared to that with the MGIT 960, and clinically useful quantitative interpretation was also provided.

Indexed as

Antitubercular AgentsExtensively Drug-Resistant TuberculosisMicrobial Sensitivity TestsMycobacterium tuberculosisTanzaniaAntitubercular Agents

Identifiers

PMID26303804
PMCPMC4604373
OpenAlexW2273991877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.