Trial reportJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2015
Higher Treadmill Training Intensity to Address Functional Aerobic Impairment after Stroke.
Trial report in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00387712 (Inflammatory Abnormalities in Muscle After Stroke), which is not on this map. Cited by 33 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Inflammatory Abnormalities in Muscle After Stroke: Effects of Exercise
Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Effectiveness of Physical Rehabilitation Interventions on Walking Capacity and Wearable Sensor-Derived Performance After Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Sensors (Basel, Switzerland) · 2026Pooled it
- Brazilian Guideline for Exercise Test in the Adult Population - 2024.Arquivos brasileiros de cardiologia · 2024Guideline
- Comparative efficacy of different exercise methods to improve cardiopulmonary function in stroke patients: a network meta-analysis of randomized controlled trials.Frontiers in neurology · 2024Pooled it
- Factors Influencing the Efficacy of Aerobic Exercise for Improving Fitness and Walking Capacity After Stroke: A Meta-Analysis With Meta-Regression.Archives of physical medicine and rehabilitation · 2017Pooled it
- High-intensity interval training after stroke: a three-level random-effects meta-analysis with cluster-robust inference and exploratory dose-parameter signals.Frontiers in neurologyPooled it
- Quantifying Exercise Intensity to Predict Changes in Walking Capacity in Individuals with Chronic Stroke.Archives of physical medicine and rehabilitation · 2026Trial
- Is training speed an accurate predictor of who attains a minimal clinically important difference in the six-minute walk test in people with chronic stroke?Topics in stroke rehabilitation · 2025Trial
- Trial
- Randomization to Treadmill Training Improves Physical and Metabolic Health in Association With Declines in Oxidative Stress in Stroke.Archives of physical medicine and rehabilitation · 2022Trial
- Effect of combined home-based, overground robotic-assisted gait training and usual physiotherapy on clinical functional outcomes in people with chronic stroke: A randomized controlled trial.Clinical rehabilitation · 2021Trial
- Metabolomics of Aerobic Exercise in Chronic Stroke Survivors: A Pilot Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Trial
- Effects of aerobic training on physical activity in people with stroke: protocol for a randomized controlled trial.Trials · 2018Trial
- Effects of Training Intensity on Locomotor Performance in Individuals With Chronic Spinal Cord Injury: A Randomized Crossover Study.Neurorehabilitation and neural repairTrial
- Using Exercise Intensity to Predict a Minimal Clinically Important Difference in the Six-Minute Walk Test in People with Chronic Stroke.medRxiv : the preprint server for health sciences · 2025Article
- Taking the Next Step in Neurologic Rehabilitation: Contributions of Intensity and Variability of Stepping Tasks During Locomotor Training.Physical therapy · 2025Review
- The Efficacy of HIIT Programs for the Improvement of Aerobic Capacity and Functionality for Stroke Survivors: Systematic Review and Meta-Analysis.Neurology research international · 2025Review
- Tailoring interval training in stroke rehabilitation: The role of peak velocity.Journal of rehabilitation research and practice · 2025Article
- High-Intensity Exercise Training Impact on Cardiorespiratory Fitness, Gait Ability, and Balance in Stroke Survivors: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Impact of Focal Muscle Vibration on Flaccid Upper Limb Motor Paralysis following Acute Brain Disease: A Case Study.Case reports in neurological medicine · 2024Article
- Elucidating the role of physical exercises in alleviating stroke-associated homeostatic dysregulation: a systematic review and meta-analysis.BMJ open sport & exercise medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPeak aerobic capacity (VO2 peak) is severely worsened after disabling stroke, having serious implications for function, metabolism, and ongoing cardiovascular risk. Work from our laboratory and others has previously shown that modest improvements in VO2 peak are possible in stroke participants with aerobic exercise training. The purpose of the current investigation was to test the extent to which greater enhancements in VO2 peak after stroke are possible using a treadmill protocol with far greater emphasis on intensity progression compared with a protocol without such emphasis.
methodsUsing a randomized design, we compared stroke survivors engaged in higher intensity treadmill training (HI-TM, 80% heart rate reserve [HRR]) with those undergoing lower intensity treadmill training (LO-TM, 50% HRR). Measured outcomes were change in VO2 peak, 6-minute walk distance (6MWD), 30-ft walk times (30WT), and 48-hour step counts (48SC). LO-TM participants trained for a longer period of time per session in an effort to approximately match workload/caloric expenditure. Participants were randomized with stratification according to age and baseline walking capacity.
resultsHI-TM participants (n = 18) had significantly greater gains in VO2 peak (+34%) than LO-TM participants (n = 16; +5%) across the 6-month intervention period (P = .001, group × time interaction). Conversely, there was no statistical difference between groups in the changes observed for 6MWD, 30WT, or 48SC.
conclusionsHI-TM is far more effective than LO-TM for improving VO2 peak after disabling stroke. The magnitude of relative improvement for HI-TM was double compared with previous reports from our laboratory with probable clinical significance for this population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.