ArticleBMC complementary and alternative medicine2015
Antimicrobial and cytotoxicity properties of the crude extracts and fractions of Premna resinosa (Hochst.) Schauer (Compositae): Kenyan traditional medicinal plant.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 38 citations in OpenAlex.
- Antiproliferative activity, phytochemistry, network pharmacology, molecular docking and gene expression analysis of Maerua edulis extracts against human cervical cancer cell line.BMC complementary medicine and therapies · 2026Article
- Sperm-disrupting activity of a root bark fraction ofFrontiers in pharmacology · 2026Article
- Extracts from Plectranthus asirensis and Premna resinosa inhibit Helicobacter pylori-induced epithelial cell damage, DNA double-strand breaks and inflammation.Gut pathogens · 2025Article
- Phytochemical analysis,Frontiers in pharmacology · 2024Article
- Phytochemical Composition and Bioactivities of Aqueous Extract of Rambutan (Antioxidants (Basel, Switzerland) · 2022Article
- A Systematic Review of Medicinal Plants of Kenya used in the Management of Bacterial Infections.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Antibacterial Activity ofAntibiotics (Basel, Switzerland) · 2021Article
- In vitro cytotoxicity of Aspilia pluriseta Schweinf. extract fractions.BMC research notes · 2021Article
- Antibacterial and Antifungal Activities of Ethiopian Medicinal Plants: A Systematic Review.Frontiers in pharmacology · 2021Article
- Antimicrobial activity, phytochemical characterization and gas chromatography-mass spectrometry analysis ofHeliyon · 2020Article
- Antibacterial and cytotoxic activity assessment ofVeterinary world · 2020Article
- The first report on theSaudi journal of biological sciences · 2019Article
- A high-throughput screening campaign to identify inhibitors of DXP reductoisomerase (IspC) and MEP cytidylyltransferase (IspD).Analytical biochemistry · 2018Article
- Antimicrobial, anticancer, and antioxidant compounds from Premna resinosa growing in Saudi Arabia.Pharmaceutical biology · 2017Article
- Screening for biomarkers of liver injury induced by Polygonum multiflorum: a targeted metabolomic study.Frontiers in pharmacology · 2015Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPremna resinosa (Hochst.) Schauer also called "mukarakara" in Mbeere community of Kenya is used in the management of respiratory illness. In this study we investigated antituberculous, antifungal, antibacterial activities including cytotoxicity and phytochemical constituents of this plant.
methodsAntibacterial and antifungal activities were investigated by disc diffusion and micro dilution techniques. Antituberculous activity was investigated using BACTEC MGIT 960 system while cytotoxicity was analyzed by MTT assay on Vero cells (Methanolic crude extract) and HEp-2 cells (fractions). Finally, phytochemicals were profiled using standard procedures.
resultsP. resinosa had high antituberculous activity with a MIC of <6.25 μg/ml in ethyl acetate fraction. The antibacterial activity was high and broad spectrum, inhibiting both Gram positive and Gram negative bacteria. Dichloromethane fraction had the best antibacterial MIC of 31.25 μg/ml against Methicillin-resistant S. aureus while Ethyl acetate fraction had the highest zone of inhibition of 22.3±0.3 against S. aureus. Its effects on tested fungi were moderate with petro ether fraction giving an inhibition of 10.3±0.3 on C. albicans. The crude extract and two fractions (petro ether and methanol) were not within the acceptable toxicity limits, however dichloromethane and ethyl acetate fractions that exhibited higher activity were within the acceptable toxicity limit (CC50<90). The activity can to some extent be associated to alkaloids, flavonoids, terpenoids, anthraquinones and phenols detected in this plant extracts.
conclusionOur findings demonstrate that P. resinosa has high selective potential as a source of novel lead for antituberculous, antibacterial and antifungal drugs. Of particular relevance is high activity against MRSA, S. aureus, C. albicans and MTB which are great public health challenge due to drug resistance development and as major sources of community and hospital based infections.
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