ArticleInternational journal of legal medicine2016
Age estimation based on aspartic acid racemization in human sclera.
Article in International journal of legal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Advancing Forensic Human Chronological Age Estimation: Biochemical, Genetic, and Epigenetic Approaches from the Last 15 Years: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Molecular age estimation based on posttranslational protein modifications in bone: why the type of bone matters.International journal of legal medicine · 2023Article
- Analysis ofBiomolecules · 2021Article
- NanoSIMS observations of mouse retinal cells reveal strict metabolic controls on nitrogen turnover.BMC molecular and cell biology · 2021Article
- Age estimation based on different molecular clocks in several tissues and a multivariate approach: an explorative study.International journal of legal medicine · 2020Article
- Differences in non-enzymatic glycation products in human dentine and clavicle: changes with aging.International journal of legal medicine · 2018Article
- Tissue aging: the integration of collective and variant responses of cells to entropic forces over time.Current opinion in cell biology · 2018Review
- Age estimation based on aspartic acid racemization in dentine: what about caries-affected teeth?International journal of legal medicine · 2018Article
- Old Proteins in Man: A Field in its Infancy.Trends in biochemical sciences · 2016Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age estimation based on racemization of aspartic acid residues (AAR) in permanent proteins has been established in forensic medicine for years. While dentine is the tissue of choice for this molecular method of age estimation, teeth are not always available which leads to the need to identify other suitable tissues. We examined the suitability of total tissue samples of human sclera for the estimation of age at death. Sixty-five samples of scleral tissue were analyzed. The samples were hydrolyzed and after derivatization, the extent of aspartic acid racemization was determined by gas chromatography. The degree of AAR increased with age. In samples from younger individuals, the correlation of age and D-aspartic acid content was closer than in samples from older individuals. The age-dependent racemization in total tissue samples proves that permanent or at least long-living proteins are present in scleral tissue. The correlation of AAR in human sclera and age at death is close enough to serve as basis for age estimation. However, the precision of age estimation by this method is lower than that of age estimation based on the analysis of dentine which is due to molecular inhomogeneities of total tissue samples of sclera. Nevertheless, the approach may serve as a valuable alternative or addition in exceptional cases.
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