ArticleMolecular psychiatry2016
Electrical stimulation in the bed nucleus of the stria terminalis alleviates severe obsessive-compulsive disorder.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 10 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
125 citing papers in PubMed, 10 syntheses or guidelines pooled it, 246 citations in OpenAlex.
- Predictors of deep brain stimulation response in patients with obsessive compulsive disorder: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Bed nucleus of the stria terminalis deep brain stimulation in treatment-refractory obsessive-compulsive disorder: a systematic review.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Proton Density MR Imaging: A Simple and Powerful Sequence to Visualise Anatomical Structures in Functional Neurosurgery.Stereotactic and functional neurosurgery · 2026Pooled it
- Circuit-based neuromodulation for obsessive-compulsive disorder: a systematic review, meta-analysis, and translational case study.Journal of psychiatry & neuroscience : JPN · 2026Pooled it
- Deep brain stimulation for obsessive-compulsive-disorder: a systematic review and meta-analysis of individual participant outcome data from sham-controlled trials.Molecular psychiatry · 2025Pooled it
- Seizure incidence after deep brain stimulation: a meta-analysis of risk factors and target-specific outcomes in non-epileptic disorders.Neurosurgical review · 2025Pooled it
- Pooled it
- Invasive and Non-invasive Neurostimulation for OCD.Current topics in behavioral neurosciences · 2021Pooled it
- A Systematic Review of Deep Brain Stimulation Targets for Obsessive Compulsive Disorder.Neurosurgery · 2020Pooled it
- The effects of deep-brain non-stimulation in severe obsessive-compulsive disorder: an individual patient data meta-analysis.Translational psychiatry · 2019Pooled it
- Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial.Cell reports. Medicine · 2026Trial
- A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder.Translational psychiatry · 2021Trial
- A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder.Nature communications · 2020Trial
- A Randomized Trial Directly Comparing Ventral Capsule and Anteromedial Subthalamic Nucleus Stimulation in Obsessive-Compulsive Disorder: Clinical and Imaging Evidence for Dissociable Effects.Biological psychiatry · 2019Trial
- Deep brain stimulation for treatment-resistant major depressive disorder: a comparison of two targets and long-term follow-up.Translational psychiatry · 2017Trial
- Mechanism and progress of deep brain stimulation in the treatment of neurological and psychiatric disorders.MedScience · 2026Review
- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
- Effectiveness of Deep Brain Stimulation for Treatment-Resistant OCD: Systematic Review of Anatomical Targets and Meta-Analysis of Randomized and Non-Randomized Studies.Brain sciences · 2026Review
- Behavioural and clinical biomarkers of the human bed nucleus of stria terminalis from direct neural recordings.Brain : a journal of neurology · 2026Article
- Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation.Nature communications · 2026Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 1998, we proposed deep brain stimulation as a last-resort treatment option for patients suffering from severe, treatment-resistant obsessive-compulsive disorder (OCD). Here, 24 OCD patients were included in a long-term follow-up study to evaluate the effects of electrical stimulation in the anterior limbs of the internal capsule (ALIC) and bed nucleus of the stria terminalis (BST). We find that electrical stimulation in the ALIC/BST area is safe and significantly decreases obsessions, compulsions, and associated anxiety and depressive symptoms, and improves global functioning in a blinded crossover trial (n=17), after 4 years (n=18), and at last follow-up (up to 171 months, n=24). Moreover, our data indicate that BST may be a better stimulation target compared with ALIC to alleviate OCD symptoms. We conclude that electrical stimulation in BST is a promising therapeutic option for otherwise treatment-resistant OCD patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.