ArticleBrain imaging and behavior2016
Cortical brain atrophy and intra-individual variability in neuropsychological test performance in HIV disease.
Article in Brain imaging and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The Prevalence of Frascati-Criteria-Based HIV-Associated Neurocognitive Disorder (HAND) in HIV-Infected Adults: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Brain Structural Changes following HIV Infection: Meta-Analysis.AJNR. American journal of neuroradiology · 2018Pooled it
- Cognitive intra-individual variability in breast cancer survivors: A systematic review.Applied neuropsychology. AdultPooled it
- Exploring the potential of cognitive intra-individual variability in HIV care and research in adults with HIV: a concept analysis.Applied neuropsychology. Adult · 2026Review
- Utilizing Intraindividual Cognitive Variability to Predict Early Neuronal Synuclein Disease Progression.medRxiv : the preprint server for health sciences · 2026Article
- Does cognitive intra-individual variability predict change in everyday functioning performance in women with and without HIV in the Women's Interagency HIV Study?Applied neuropsychology. Adult · 2024Article
- Cognitive dispersion and its functional relevance in behavioral variant frontotemporal dementia and prodromal behavioral variant frontotemporal dementia.Neuropsychology · 2024Article
- Self-perceived cognitive fluctuations and their relationship to everyday functioning in older adults with and without HIV disease.The Clinical neuropsychologist · 2024Article
- Cognitive Intra-Individual Variability as an Outcome or Moderator of Speed of Processing Training in Aging Adults with HIV-Associated Neurocognitive Disorder: A Secondary Data Analysis of a 2-Year Longitudinal Randomized Clinical Trial.Archives of gerontology and geriatrics plus · 2024Article
- Ecological validity of cognitive fluctuations in dementia with Lewy bodies.Journal of the International Neuropsychological Society : JINS · 2024Article
- Lower prospective memory is associated with higher neurocognitive dispersion in two samples of people with HIV: A conceptual replication study.Journal of the International Neuropsychological Society : JINS · 2023Article
- Cognitive Intra-individual Variability in HIV: an Integrative Review.Neuropsychology review · 2022Review
- Dispersion of cognitive performance test scores on the MATRICS Consensus Cognitive Battery: A different perspective.Schizophrenia research. Cognition · 2022Article
- Intraindividual variability in neuropsychological performance predicts longitudinal cortical volume loss in early Parkinson's disease.Neuropsychology · 2022Article
- Current Considerations for Clinical Management and Care of People with HIV: Findings from the 11th Annual International HIV and Aging Workshop.AIDS research and human retroviruses · 2021Article
- Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection.Scientific reports · 2021Observational
- Elevated Intraindividual Variability in Executive Functions and Associations with White Matter Microstructure in Veterans with Mild Traumatic Brain Injury.Journal of the International Neuropsychological Society : JINS · 2021Article
- HIV-Associated Neurocognitive Disorder (HAND): Relative Risk Factors.Current topics in behavioral neurosciences · 2021Article
- Bridging the gap between performance-based assessment and self-reported everyday functioning: An ecological momentary assessment approach.The Clinical neuropsychologist · 2020Article
- Brief Report: Higher Peripheral Monocyte Activation Markers Are Associated With Smaller Frontal and Temporal Cortical Volumes in Women With HIV.Journal of acquired immune deficiency syndromes (1999) · 2020Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
To characterize the relationship between dispersion-based intra-individual variability (IIVd) in neuropsychological test performance and brain volume among HIV seropositive and seronegative men and to determine the effects of cardiovascular risk and HIV infection on this relationship. Magnetic Resonance Imaging (MRI) was used to acquire high-resolution neuroanatomic data from 147 men age 50 and over, including 80 HIV seropositive (HIV+) and 67 seronegative controls (HIV-) in this cross-sectional cohort study. Voxel Based Morphometry was used to derive volumetric measurements at the level of the individual voxel. These brain structure maps were analyzed using Statistical Parametric Mapping (SPM2). IIVd was measured by computing intra-individual standard deviations (ISD's) from the standardized performance scores of five neuropsychological tests: Wechsler Memory Scale-III Visual Reproduction I and II, Logical Memory I and II, Wechsler Adult Intelligence Scale-III Letter Number Sequencing. Total gray matter (GM) volume was inversely associated with IIVd. Among all subjects, IIVd -related GM atrophy was observed primarily in: 1) the inferior frontal gyrus bilaterally, the left inferior temporal gyrus extending to the supramarginal gyrus, spanning the lateral sulcus; 2) the right superior parietal lobule and intraparietal sulcus; and, 3) dorsal/ventral regions of the posterior section of the transverse temporal gyrus. HIV status, biological, and cardiovascular disease (CVD) variables were not linked to IIVd -related GM atrophy. IIVd in neuropsychological test performance may be a sensitive marker of cortical integrity in older adults, regardless of HIV infection status or CVD risk factors, and degree of intra-individual variability links with volume loss in specific cortical regions; independent of mean-level performance on neuropsychological tests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.