ReviewThe spine journal : official journal of the North American Spine Society2015
Novel diagnostic and prognostic methods for disc degeneration and low back pain.
Abstract readReview
In one paragraph
Review in The spine journal : official journal of the North American Spine Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed.
- ISSLS Prize in Bioengineering Science 2026: Hidden in Plain Sight: Machine Learning-Assisted MRI Reveals Novel Vertebral Body Biomarkers of Chronic Low Back Pain in Humans.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Article
- Bibliometric and Visualized Analysis of Research Relating to Spinal Modic Changes Reported Over the Period 2004-2024.Orthopaedic surgery · 2025Article
- Progression of lumbar disc degeneration: A 14-year follow-up study examining Pfirrmann grading and its individual disc components.Acta radiologica open · 2025Article
- Novel anti-pyroptosis drug loaded on metal-organic framework for intervertebral disc degeneration therapy.Materials today. Bio · 2025Article
- Mechanisms and management of self-resolving lumbar disc herniation: bridging molecular pathways to non-surgical clinical success.Journal of orthopaedic surgery and research · 2025Review
- Automatic Detection and Classification of Modic Changes in MRI Images Using Deep Learning: Intelligent Assisted Diagnosis System.Orthopaedic surgery · 2024Article
- Role of arachidonic acid metabolism in intervertebral disc degeneration: identification of potential biomarkers and therapeutic targets via multi-omics analysis and artificial intelligence strategies.Lipids in health and disease · 2023Article
- Metabolic Biomarkers Differentiate a Surgical Intervertebral Disc from a Nonsurgical Intervertebral Disc.International journal of molecular sciences · 2023Article
- pH-Responsive Delivery of H2 through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy.Oxidative medicine and cellular longevity · 2023Article
- Lumbar Fusion Surgery for Patients With Back Pain and Degenerative Disc Disease: An Observational Study From the Canadian Spine Outcomes and Research Network.Global spine journal · 2022Article
- Artificial intelligence in predicting early-onset adjacent segment degeneration following anterior cervical discectomy and fusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Novel Methods to Measure Height and Volume in Healthy and Degenerated Lumbar Discs in MRIs: A Reliability Assessment Study.Diagnostics (Basel, Switzerland) · 2022Article
- Mechanisms and clinical implications of intervertebral disc calcification.Nature reviews. Rheumatology · 2022Review
- Association of lumbar disc degeneration with low back pain in middle age in the Northern Finland Birth Cohort 1966.BMC musculoskeletal disorders · 2022Article
- Detailed Subphenotyping of Lumbar Modic Changes and Their Association with Low Back Pain in a Large Population-Based Study: The Wakayama Spine Study.Pain and therapy · 2022Article
- Quantum Computing: The Future of Big Data and Artificial Intelligence in Spine.Spine surgery and related research · 2022Review
- Evaluating the effect of a post-processing algorithm in detection of annular fissure on MR imaging.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021Article
- Article
- Association between types of Modic changes in the lumbar region and low back pain in a large cohort: the Wakayama spine study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Dino SamartzisDepartment of Orthopaedics and Traumatology, The University of Hong Kong, Professorial Block, 5th Floor, 102 Pokfulam Road, Pokfulam, Hong Kong, SAR, China; The Laboratory and Clinical Research Institute for Pain, The University of Hong Kong, 102 Pokfulam Road, Pokfulam, Hong Kong, SAR, China. Electronic address: dsamartzis@msn.com.
Ari BorthakurCenter for Magnetic Resonance and Optical Imaging, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, 3535 Market Street, Mezzanine, Philadelphia, PA, 19104, USA.
Inna BelferDepartment of Anesthesiology, University of Pittsburgh, 4200 Fifth Ave, Pittsburgh, PA 15260, USA.
Cora BowDepartment of Orthopaedics and Traumatology, The University of Hong Kong, Professorial Block, 5th Floor, 102 Pokfulam Road, Pokfulam, Hong Kong, SAR, China.
Jeffrey C LotzDepartment of Orthopaedic Surgery, University of California at San Francisco, 500 Parnassus Ave, San Francisco, CA 94143, USA.
Hai-Qiang WangDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, No. 169, Changle West Road, Xi'an, Shaanxi, 710032, P.R. China.
Kenneth M C CheungDepartment of Orthopaedics and Traumatology, The University of Hong Kong, Professorial Block, 5th Floor, 102 Pokfulam Road, Pokfulam, Hong Kong, SAR, China.
Eugene CarrageeDepartment of Orthopaedic Surgery, Stanford University, 450 Serra Mall, Stanford, CA 94305, USA.
Jaro KarppinenMedical Research Center Oulu, University of Oulu, Oulu University Hospital, Kajaanintie 50, 90220 Oulu, Finland.
Funding
WORKSHOP ON ADVANCES IN MUSCULOSKELETAL MRIP41RR002305 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI LICHT, DANIEL JACQUES · 1985 to 2011
$14.7MTraining and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3MPhenotypes of pathologic vertebral endplate degenerationR01AR063705 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOTZ, JEFFREY C. · 2013 to 2017
$3.0MPhenotypes of pathologic vertebral endplate degenerationR56AR063705 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOTZ, JEFFREY C. · 2019 to 2019
$669kNCRR NIH HHS P41 RR002305NIAMS NIH HHS R01 AR063705NIAMS NIH HHS R56 AR063705NIBIB NIH HHS P41 EB015893
Abstract
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Indexed as
HumansIntervertebral Disc DegenerationLow Back PainMagnetic Resonance ImagingPositron-Emission Tomography
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.