ArticleLipids in health and disease2015
Fish oil administration mediates apoptosis of Walker 256 tumor cells by modulation of p53, Bcl-2, caspase-7 and caspase-3 protein expression.
Article in Lipids in health and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Biovalorization of whey waste as economic nutriment for mycogenic production of single cell oils with promising antibiofilm and anticancer potentiality.Journal of biological engineering · 2024Article
- Ascorbic Acid Regulates the Immunity, Anti-Oxidation and Apoptosis in AbaloneAntioxidants (Basel, Switzerland) · 2021Article
- Omega-3 polyunsaturated fatty acids: a promising approach for the management of oral lichen planus.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Review
- Nephroprotective Effect ofBiomolecules · 2020Article
- Positive Effects of Preventive Nutrition Supplement on Anticancer Radiotherapy in Lung Cancer Bearing Mice.Cancers · 2020Article
- Comparative Transcriptome Analysis Provides Insights into the Polyunsaturated Fatty Acid Synthesis Regulation ofInternational journal of molecular sciences · 2020Article
- Intravenous infusion of ulinastatin attenuates acute kidney injury after cold ischemia/reperfusion.International urology and nephrology · 2019Article
- Folic acid inhibits homocysteine-induced cell apoptosis in human umbilical vein endothelial cells.Molecular and cellular biochemistry · 2018Article
- Fish Oil Contaminated with Persistent Organic Pollutants Induces Colonic Aberrant Crypt Foci Formation and Reduces Antioxidant Enzyme Gene Expression in Rats.The Journal of nutrition · 2017Article
- Article
- Effect of Combined Treatment Using Wilfortrine and Paclitaxel in Liver Cancer and Related Mechanism.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Effects of pterostilbene on treating hyperprolactinemia and related mechanisms.American journal of translational research · 2016Article
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have been shown pro-apoptotic effects of fish oil (FO), rich in n-3 polyunsaturated fatty acids (n-3 PUFA) on cancer cells. Nevertheless, few in vivo experiments have provided data of its ability on apoptosis protein expression in tumor tissue. Thus, in this study we investigate the effect of FO supplementation on apoptosis protein expression in Walker 256 tumor bearing rats. Male Wistar rats were randomly assigned to three groups: fed with regular chow (W); fed regular chow supplemented with FO (WFO) or coconut fat (WCO) (1 g/kg body weight/daily). After thirty days, all animals were inoculated subcutaneously with Walker 256 tumor cells.
findingsProtein expression was done by western blotting in Walker 256 tumor tissue samples. FO decreased the Bcl-2/Bax ratio (p < 0.05) and increased the p53 (p < 0.05), cleaved caspase-7 (p < 0.05) and cleaved caspase-3 (p < 0.05) in Walker 256 tumor tissue.
conclusionsOur data suggest that the pro-apoptotic effect of FO in Walker 256 tumor is related with specifics cleaved caspases.
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