ArticleClinical research in cardiology : official journal of the German Cardiac Society2016
Outcome predictors in cardiopulmonary resuscitation facilitated by extracorporeal membrane oxygenation.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- A Systematic Review with Meta-Analysis Investigating the Impact of Targeted Perfusion Parameters during Extracorporeal Cardiopulmonary Resuscitation in Out-of-Hospital and Inhospital Cardiac Arrest.The journal of extra-corporeal technology · 2022Pooled it
- Neurological outcome after extracorporeal cardiopulmonary resuscitation for in-hospital cardiac arrest: a systematic review and meta-analysis.Critical care (London, England) · 2020Pooled it
- Comparing clinical only and combined clinical laboratory models for ECPR outcomes in refractory cardiac arrest.Scientific reports · 2025Article
- Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial.Resuscitation plus · 2024Article
- Extracorporeal cardiopulmonary resuscitation in adults and children: A review of literature, published guidelines and pediatric single-center program building experience.Frontiers in medicine · 2022Review
- Blood lactate predicts survival after percutaneous implantation of extracorporeal life support for refractory cardiac arrest or cardiogenic shock complicating acute coronary syndrome: insights from the CareGem registry.Internal and emergency medicine · 2021Article
- Extracorporeal cardiopulmonary resuscitation for adults with shock-refractory cardiac arrest.Journal of the American College of Emergency Physicians open · 2021Review
- Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest in Adult Patients.Journal of the American Heart Association · 2020Review
- Real-world clinical experience with the percutaneous extracorporeal life support system: Results from the German LifebridgeClinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Lactate Clearance Predicts Good Neurological Outcomes in Cardiac Arrest Patients Treated with Extracorporeal Cardiopulmonary Resuscitation.Journal of clinical medicine · 2019Article
- Impact of Age-Adjusted Charlson Comorbidity on Hospital Survival and Short-Term Outcome of Patients with Extracorporeal Cardiopulmonary Resuscitation.Journal of clinical medicine · 2018Article
- Cerebral Near-Infrared Spectroscopy in Adult Patients Undergoing Veno-Arterial Extracorporeal Membrane Oxygenation.Neurocritical care · 2018Article
- Incidence, laboratory detection and prognostic relevance of hypoxic hepatitis in cardiogenic shock.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Review
- Article
- Comparison of extracorporeal and conventional cardiopulmonary resuscitation: A meta-analysis of 2 260 patients with cardiac arrest.World journal of emergency medicine · 2017Article
- Extracorporeal Life Support and New Therapeutic Strategies for Cardiac Arrest Caused by Acute Myocardial Infarction - a Critical Approach for a Critical Condition.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2016Article
- Liver function during mechanical circulatory support: from witness to prognostic determinant.Critical care (London, England) · 2016Article
- Cannulation strategies for percutaneous extracorporeal membrane oxygenation in adults.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Review
- Extracorporeal Membrane Oxygenation as a Bridge for Heart Failure and Cardiogenic Shock.BioMed research international · 2016Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCardiac arrest is the major cause of sudden death in developed countries. Extracorporeal cardiopulmonary resuscitation (ECPR) employs extracorporeal membrane oxygenation (ECMO) in patients without return of spontaneous circulation (ROSC) by conventional cardiopulmonary resuscitation (CPR). Aim of the current study was to assess short- and long-term outcome in patients treated with ECPR in our tertiary center and to identify predictors of outcome.
methodsWe retrospectively collected data of all patients treated with ECPR at our institution from 2002 to 2013. Outcome was assessed according to patient records; good neurological outcome was defined as cerebral performance category 1 or 2. Quality of life data was collected using EQ-5 questionnaire. Uni- and multivariate analysis was applied to identify predictors of outcome.
resultsOne-hundred and seventeen patients were included into the study. Weaning from ECMO was successful in 61 (52 %) patients. Thirty-day survival endpoint was achieved by 27 (23 %) patients. Good neurological outcome was present in 17 (15 %) patients. Multivariate analysis revealed baseline serum lactate as the strongest predictor of outcome, whereas age and out-of-hospital CPR did not predict outcome. The optimal lactate cut-off to discriminate outcome was determined at 4.6 mmol/l [HR 3.55 (2.29-5.49), p < 0.001, log-rank test].
conclusionECPR represents a treatment option in patients without ROSC after conventional CPR rescuing 15 % of patients with good neurological outcome. Serum lactate may play a crucial role in patient selection for ECPR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.