ArticleBMC biology2015
Was Cajal right about sleep?
Article in BMC biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Astrocytes Regulate Brain State Transitions.Neurochemical research · 2025Review
- Calcium signaling at the interface between astrocytes and brain inflammation.Current opinion in neurobiology · 2025Review
- Glymphatic System and Psychiatric Disorders: A Rapid Comprehensive Scoping Review.Current neuropharmacology · 2024Article
- Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly.Annual review of neuroscience · 2023Review
- Article
- The Glial Perspective on Sleep and Circadian Rhythms.Annual review of neuroscience · 2020Review
- Exploring the Role of Astroglial Glutamate Release and Association With Synapses in Neuronal Function and Behavior.Biological psychiatry · 2018Review
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cajal's careful observations of the anatomy of the nervous system led him to some lesser-known predictions about the function of glia as mediators of sleep. Reporting over 120 years later in BMC Biology, Bellesi et al. examine changes in gene expression and morphology of astrocytes with sleep. Their results provide support for and revisions to Cajal's predictions.See research article: doi: 10.1186/s12915-015-0176-7 .
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.