SynthesisScientific reports2015
Coffee consumption and risk of endometrial cancer: a dose-response meta-analysis of prospective cohort studies.
Synthesis in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 6 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Pooled it
- Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes.BMJ (Clinical research ed.) · 2017Pooled it
- Coffee Decreases the Risk of Endometrial Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies.Nutrients · 2017Pooled it
- Coffee Consumption and the Risk of Thyroid Cancer: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2017Pooled it
- Coffee consumption and the risk of cutaneous melanoma: a meta-analysis.European journal of nutrition · 2016Pooled it
- Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study.PloS one · 2016Pooled it
- Gene Expression Profiling of Peripheral Blood and Endometrial Cancer Risk Factors: Systems Epidemiology Approach in the NOWAC Postgenome Cohort Study.Lifestyle genomics · 2026Article
- Coffee consumption, cancer, and healthy aging: epidemiological evidence and underlying mechanisms.GeroScience · 2025Review
- Resolution of Symptoms of Suspected Nonatypical Endometrial Hyperplasia Using Herbal Medicine Modified Sihogyeji-Tang Monotherapy: A Case Report with Ultrasound Monitoring.Life (Basel, Switzerland) · 2025Article
- Association of caffeine intake with all-cause and cardiovascular mortality in diabetes and prediabetes.Diabetology & metabolic syndrome · 2024Article
- Effects of coffee intake on airway hypersensitivity and immunomodulation: anNutrition research and practice · 2023Article
- Causal assessment in evidence synthesis: A methodological review of reviews.Research synthesis methods · 2022Review
- Review of Mendelian Randomization Studies on Endometrial Cancer.Frontiers in endocrinology · 2022Review
- Molecular Basis of Endometriosis and Endometrial Cancer: Current Knowledge and Future Perspectives.International journal of molecular sciences · 2021Review
- A Decade of Research on Coffee as an Anticarcinogenic Beverage.Oxidative medicine and cellular longevity · 2021Review
- Article
- Metabolites, Nutrients, and Lifestyle Factors in Relation to Coffee Consumption: An Environment-Wide Association Study.Nutrients · 2020Article
- A prospective study of tea and coffee intake and risk of glioma.International journal of cancer · 2020Article
- Association between coffee drinking and telomere length in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.PloS one · 2020Article
- Risk factors for childhood and adult primary brain tumors.Neuro-oncology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This is a dose-response (DR) meta-analysis to evaluate the association of coffee consumption on endometrial cancer (EC) risk. A total 1,534,039 participants from 13 published articles were added in this meta-analysis. The RR of total coffee consumption and EC were 0.80 (95% CI: 0.74-0.86). A stronger association between coffee intake and EC incidence was found in patients who were never treated with hormones, 0.60 (95% CI: 0.50-0.72), and subjects with a BMI ≥25 kg/m(2), 0.57 (95% CI: 0.46-0.71). The overall RRs for caffeinated and decaffeinated coffee were 0.66 (95% CI: 0.52-0.84) and 0.77 (95% CI: 0.63-0.94), respectively. A linear DR relationship was seen in coffee, caffeinated coffee, decaffeinated coffee and caffeine intake. The EC risk decreased by 5% for every 1 cup per day of coffee intake, 7% for every 1 cup per day of caffeinated coffee intake, 4% for every 1 cup per day of decaffeinated intake of coffee, and 4% for every 100 mg of caffeine intake per day. In conclusion, coffee and intake of caffeine might significantly reduce the incidence of EC, and these effects may be modified by BMI and history of hormone therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.