ArticleRadiation oncology (London, England)2015
Lymph node ratio as a prognostic factor in head and neck cancer patients.
Article in Radiation oncology (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Application of artificial intelligence and radiomics in the prediction of lymph node metastasis and tumour grading of oral cancer - a systematic review and meta analysis.BMC oral health · 2026Pooled it
- Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: a systematic review and meta-analysis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2020Pooled it
- High-risk lymph node ratio predicts worse prognosis in patients with locally advanced oral cancer.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2020Trial
- Distant lymph nodes compensate for resected tumor-draining lymph nodes during cancer immunotherapy.Immunity · 2026Article
- Article
- Prognostic value of FNA-Tg for local recurrence following lateral neck dissection in papillary thyroid carcinoma.BMC endocrine disorders · 2026Article
- Automated Lymph Node Localization and Segmentation in Patients with Head and Neck Cancer: Opportunities and Limitations of Using a Generic AI Model.Diagnostics (Basel, Switzerland) · 2026Article
- Review
- Prognostic Heterogeneity Between Oral Tongue and Gingivobuccal Tumours Based on Lymph Node Ratio and Number of Positive Nodes: A Survival Analysis.Journal of maxillofacial and oral surgery · 2024Article
- Optimal Extent of Neck Dissection for a Head and Neck Lymph Node Metastasis from a Remote Primary Site.Journal of clinical medicine · 2024Article
- Reconstructive flap surgery in head and neck cancer patients: an interdisciplinary view of the challenges encountered by radiation oncologists in postoperative radiotherapy.Frontiers in oncology · 2024Review
- A Site-Based Analysis of Relationship Between Clinicopathological Factors and Their Influence on Locoregional Recurrence in Oral Squamous Cell Carcinoma.Indian journal of surgical oncology · 2023Article
- Comparable Accuracy of Quantitative and Visual Analyses of [Diagnostics (Basel, Switzerland) · 2023Article
- Lymph Node Ratio as a Prognostic Factor in Neck Dissection in Oral Cancer Patients: A Systematic Review and Meta-Analysis.Cancers · 2022Review
- The Prognostic Prediction Value of Positive Lymph Nodes Numbers for the Hypopharyngeal Squamous Cell Carcinoma.Frontiers in medicine · 2022Article
- CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021Article
- Lymph node metastases >5 and metastatic lymph node ratio >0.30 of differentiated thyroid cancer predict response to radioactive iodine.Cancer medicine · 2021Article
- Application of radiomics and machine learning in head and neck cancers.International journal of biological sciences · 2021Review
- Evaluation of lymph node ratio and lymph node yield as prognosticators of locoregional recurrence in p16-associated oropharyngeal squamous cell carcinoma.Head & neck · 2020Article
- Definitive chemoradiotherapy in patients with squamous cell cancers of the head and neck - results from an unselected cohort of the clinical cooperation group "Personalized Radiotherapy in Head and Neck Cancer".Radiation oncology (London, England) · 2020Article
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3 authors.
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Abstract
backgroundLymph node status is one prognostic factor in head and neck cancer. The purpose of this study is to investigate the prognostic value of lymph node ratio (LNR) in head and neck cancer patients who received surgery plus postoperative chemoradiotherapy.
methodsFrom May 1991 to December 2012, a total of 117 head and neck cancer patients who received surgery plus postoperative chemoradiotherapy were analyzed. The primary sites were oral cavity (93), oropharynx (13), hypopharynx (6), and larynx (5). All patients had pathologically confirmed squamous cell carcinoma and 63 patients had neck lymph nodes metastasis. LNR was calculated for each patient. The endpoints were overall survival (OS), local failure-free survival (LFFS), and distant metastasis-free survival (DMFS).
resultsThe median follow up time was 36 months, with a range from 3.4 to 222 months. The 3-year rates of OS, LFFS, and DMFS were 59.7, 70.3, and 81.8%, respectively. The median value of LNR for lymph nodes positive patients was 0.1. In univariate analysis, patients with an LNR value less than 0.1 had better 3-year OS (67.0% vs.41.0%, p = 0.004), 3-year LFFS (76.1% vs. 54.9%, p = 0.015) and 3-year DMFS (87.2% vs. 66.4%, p = 0.06). Multivariate analysis revealed that LNR was an independent prognostic factor for OS (hazard ratio [HR] = 2.92; 95% confidence interval [CI] = 1.367-6.242; p = 0.006) and LFFS (HR = 4.12; 95% CI = 1.604-10.59; p = 0.003).
conclusionLNR is an important prognosis factor for OS and LFFS in head and neck cancer patients.
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