ReviewPediatric neurology2015
Brain Injury in the Preterm Infant: New Horizons for Pathogenesis and Prevention.
Review in Pediatric neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Effect of tactile and/or kinesthetic stimulation therapy of preterm infants on their parents' anxiety and depressive symptoms: A systematic review.BMC psychology · 2024Pooled it
- MRI-based brain volumes of preterm infants at term: a systematic review and meta-analysis.Archives of disease in childhood. Fetal and neonatal edition · 2022Pooled it
- Machine Learning-Assisted Autism Risk Stratification in Toddlers Using the Vietnamese M-CHAT-R and Perinatal Predictors: A Cross-Sectional Study in Vietnam.Journal of autism and developmental disorders · 2026Article
- Short- and Long-Term Effects of Sodium Phenylbutyrate on White Matter and Sensorimotor and Cognitive Behavior in a Mild Murine Model of Encephalopathy of Prematurity.International journal of molecular sciences · 2025Article
- Prenatal inflammation exacerbates hyperoxia-induced neonatal brain injury.Journal of neuroinflammation · 2025Article
- Chronic Inflammation Offers Hints About Viable Therapeutic Targets for Preeclampsia and Potentially Related Offspring Sequelae.International journal of molecular sciences · 2024Review
- Role of the Gut Microbiota-Brain Axis in Brain Damage in Preterm Infants.ACS pharmacology & translational science · 2024Review
- [Effects of α1-antitrypsin on motor function in mice with immature brain white matter injury].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Pathogenesis from the microbial-gut-brain axis in white matter injury in preterm infants: A review.Frontiers in integrative neuroscience · 2023Review
- Oligodendrocyte Progenitor Cell Transplantation Ameliorates Preterm Infant Cerebral White Matter Injury in Rats Model.Neuropsychiatric disease and treatment · 2023Article
- A comparison of altered white matter microstructure in youth born with congenital heart disease or born preterm.Frontiers in neurology · 2023Article
- The Joint Observation in Neonatology and Neurodevelopmental Outcome of Preterm Infants at Six Months Corrected Age: Secondary Outcome Data from a Randomised Controlled Trial.Children (Basel, Switzerland) · 2022Article
- Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic-ischemic white matter damage.CNS neuroscience & therapeutics · 2022Article
- Advanced Brain Imaging in Preterm Infants: A Narrative Review of Microstructural and Connectomic Disruption.Children (Basel, Switzerland) · 2022Review
- Choline Kinetics in Neonatal Liver, Brain and Lung-Lessons from a Rodent Model for Neonatal Care.Nutrients · 2022Article
- White Matter Injury in Preterm Infants: Pathogenesis and Potential Therapy From the Aspect of the Gut-Brain Axis.Frontiers in neuroscience · 2022Review
- Extremely preterm children and relationships of minor neurodevelopmental impairments at 6 years.Frontiers in psychology · 2022Article
- Early structural connectivity within the sensorimotor network: Deviations related to prematurity and association to neurodevelopmental outcome.Frontiers in neuroscience · 2022Article
- Protocol for a prospective multicenter longitudinal randomized controlled trial (CALIN) of sensory-tonic stimulation to foster parent child interactions and social cognition in very premature infants.Frontiers in pediatrics · 2022Article
- Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR2.JCI insight · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Preterm neonates are surviving with a milder spectrum of motor and cognitive disabilities that appear to be related to widespread disturbances in cell maturation that target cerebral gray and white matter. Whereas the preterm brain was previously at high risk for destructive lesions, preterm survivors now commonly display less severe injury that is associated with aberrant regeneration and repair responses that result in reduced cerebral growth. Impaired cerebral white matter growth is related to myelination disturbances that are initiated by acute death of premyelinating oligodendrocytes, but are followed by rapid regeneration of premyelinating oligodendrocytes that fail to normally mature to myelinating cells. Although immature neurons are more resistant to cell death than mature neurons, they display widespread disturbances in maturation of their dendritic arbors and synapses, which further contributes to impaired cerebral growth. Thus, even more mild cerebral injury involves disrupted repair mechanisms in which neurons and premyelinating oligodendrocytes fail to fully mature during a critical window in development of neural circuitry. These recently recognized distinct forms of cerebral gray and white matter dysmaturation raise new diagnostic challenges and suggest new therapeutic strategies to promote brain growth and repair.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.