ArticleeLife2015
Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 78 citations in OpenAlex.
- Review
- Cryopreserved Human Otic Neuronal Spheroids Self-assemble for Functional Connectivity Analysis and Long-term Ototoxicity Evaluation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity.eLife · 2025Article
- EPHRIN-A1 and -A2 act as positive growth factors for developing spiral ganglion radial bundles.Developmental biology · 2025Article
- Chromatin remodeling protein CHD4 regulates axon guidance of spiral ganglion neurons in the developing cochlea.bioRxiv : the preprint server for biology · 2025Article
- Semaphorin 3f and post-embryonic regulation of retinal progenitors.PLoS genetics · 2025Article
- Biallelic variants of SEMA3F are associated with nonsyndromic hearing loss.Molecules and cells · 2025Article
- Article
- The geometry of photopolymerized topography influences neurite pathfinding by directing growth cone morphology and migration.Journal of neural engineering · 2024Article
- Metabonomics and Transcriptomics Analyses Reveal the Development Process of the Auditory System in the Embryonic Development Period of the Small Yellow Croaker under Background Noise.International journal of molecular sciences · 2024Article
- The transcription factorFrontiers in cellular neuroscience · 2024Article
- Decreasing the physical gap in the neural-electrode interface and related concepts to improve cochlear implant performance.Frontiers in neuroscience · 2024Review
- Runx1 controls auditory sensory neuron diversity in mice.Developmental cell · 2023Article
- Generation of innervated cochlear organoid recapitulates early development of auditory unit.Stem cell reports · 2023Article
- Cochlear hair cell innervation is dependent on a modulatory function of Semaphorin-3A.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- Specification of neuronal subtypes in the spiral ganglion begins prior to birth in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification.Nature communications · 2022Article
- Making sense of neural development by comparing wiring strategies for seeing and hearing.Science (New York, N.Y.) · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Auditory function is dependent on the formation of specific innervation patterns between mechanosensory hair cells (HCs) and afferent spiral ganglion neurons (SGNs). In particular, type I SGNs must precisely connect with inner HCs (IHCs) while avoiding connections with nearby outer HCs (OHCs). The factors that mediate these patterning events are largely unknown. Using sparse-labeling and time-lapse imaging, we visualized for the first time the behaviors of developing SGNs including active retraction of processes from OHCs, suggesting that some type I SGNs contact OHCs before forming synapses with IHCs. In addition, we demonstrate that expression of Semaphorin-3F in the OHC region inhibits type I SGN process extension by activating Neuropilin-2 receptors expressed on SGNs. These results suggest a model in which cochlear innervation patterns by type I SGNs are determined, at least in part, through a Semaphorin-3F-mediated inhibitory signal that impedes processes from extending beyond the IHC region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.