ArticlePloS one2015
Clinical Features for Mild Hand, Foot and Mouth Disease in China.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Systematic Proteomic Characterization of EV-A71-Infected Mice Identifies Dynamic Molecular Changes and Therapeutic Targets.MedComm · 2026Article
- Clinical, aetiological, and epidemiological studies of outpatient cases of hand, foot, and mouth disease in Chengdu, China, from 2019 to 2022: a retrospective study.BMC public health · 2024Article
- Correlation analysis of serum inflammatory cytokine levels and immune markers in children with severe hand, foot and mouth disease.The Journal of international medical research · 2024Article
- A Potential Use of Vidarabine: Alleviation of Functional Constipation Through Modulation of the Adenosine A2A Receptor-MLC Signaling Pathway and the Gut Microbiota.International journal of molecular sciences · 2024Article
- Coxsackievirus A6 U.K. Genetic and Clinical Epidemiology Pre- and Post-SARS-CoV-2 Emergence.Pathogens (Basel, Switzerland) · 2024Article
- Non-linear association between daily mean temperature and children's hand foot and mouth disease in Chongqing, China.Scientific reports · 2023Article
- Impact of meteorological factors on the incidence of hand-foot-mouth disease in Yangzhou from 2017 to 2022: a time series study.Frontiers in public health · 2023Article
- Changing serotypes of hand, foot and mouth disease in Shanghai, 2017-2019.Gut pathogens · 2022Article
- Herbal Granules of Heat-Clearing and Detoxifying for Children with Mild Hand, Foot, and Mouth Disease: A Bayesian Network Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- First seroepidemiological investigation of human enterovirus 71 in Iran.Iranian journal of microbiology · 2021Article
- Early warning of hand, foot, and mouth disease transmission: A modeling study in mainland, China.PLoS neglected tropical diseases · 2021Article
- Intrinsic apoptosis and cytokine induction regulated in human tonsillar epithelial cells infected with enterovirus A71.PloS one · 2021Article
- Association between platelet count and the risk and progression of hand, foot, and mouth disease among children.Clinics (Sao Paulo, Brazil) · 2020Article
- The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017.Scientific reports · 2019Article
- Epidemiological study on hand, foot and mouth disease in Tongzhou District, Beijing, 2013-2017.The Journal of international medical research · 2019Article
- MRI reveals segmental distribution of enterovirus lesions in the central nervous system: a probable clinical evidence of retrograde axonal transport of EV-A71.Journal of neurovirology · 2019Article
- Epidemiology of 45,616 suspect cases of Hand, Foot and Mouth Disease in Chongqing, China, 2011-2015.Scientific reports · 2017Article
- Serum cholinesterase: a potential assistant biomarker for hand, foot, and mouth disease caused by enterovirus 71 infection.Infectious diseases of poverty · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMild hand, foot and mouth disease (HFMD) is at a critical stage owing to its ease of communicability and a higher risk of developing severe complications and death. Clinical diagnosis of mild HFMD was made by the presenting symptoms and signs (symptoms in brief) alone. We aim to evaluate the frequencies of symptoms in a retrospective case series study.
methodsWe collected epidemiological, demographic, clinical, and laboratory data from outpatient and inpatient settings on the clinical data warehouse system. We principally described the frequencies of symptoms of mild HFMD. Correlations between symptoms with laboratory-confirmed cases were then analyzed.
resultsThe clinical data warehouse system included 3649 probable cases, between 2010 and 2012, of which 956 (26.20%) were laboratory confirmed. The peak incidence was identified in children 2 years of age. A total of 370 of the 956 laboratory confirmed cases (38.70%) were associated with enterovirus 71 (EV71). Logistic regression analysis adjusted for geographical variables, age, sex, month of onset, and time from onset to diagnosis showed that the clinical features constipation (P<0.0001; adjusted OR, 95%CI (2.99, 2.28-3.91)), and blisters (P<0.0001; adjusted OR, 95%CI (2.16, 1.82-2.56)) were positively correlated with the confirmed cases.
conclusionsThis is the largest case series study, including all the guideline-mentioned symptoms of mild HFMD. Our findings suggest that blisters and constipation should be considered as potential warning signs while front-line clinicians manage surges of children diagnosed with mild HFMD during a pandemic.
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