ArticleJournal of abnormal psychology2015
Functional coherence of insula networks is associated with externalizing behavior.
Article in Journal of abnormal psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Third-Trimester Development of Central Autonomic Network Connectivity Is Altered in an Extrauterine Environment.Neonatology · 2025Article
- Neuroticism and openness exhibit an anti-correlation pattern to dissociable default mode network: using resting connectivity and structural equation modeling analysis.Brain imaging and behavior · 2024Article
- Tuina therapy promotes behavioral improvement and brain plasticity in rats with peripheral nerve injury and repair.Brain and behavior · 2023Article
- Article
- Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales.Human brain mapping · 2022Article
- Impact of Independent Component Analysis Dimensionality on the Test-Retest Reliability of Resting-State Functional Connectivity.Brain connectivity · 2021Article
- Salience and central executive networks track overgeneralization of conditioned-fear in post-traumatic stress disorder.Psychological medicine · 2021Article
- Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- Machine learning approaches for parsing comorbidity/heterogeneity in antisociality and substance use disorders: A primer.Personality neuroscience · 2021Article
- Toward a Neural Model of the Openness-Psychoticism Dimension: Functional Connectivity in the Default and Frontoparietal Control Networks.Schizophrenia bulletin · 2020Article
- Insular Risk Processing Predicts Alcohol Use Via Externalizing Pathway in Male Adolescents.Journal of studies on alcohol and drugs · 2019Article
- Effects of heroin on rat prosocial behavior.Addiction biology · 2019Article
- Extending the Construct Network of Trait Disinhibition to the Neuroimaging Domain: Validation of a Bridging Scale for Use in the European IMAGEN Project.Assessment · 2019Article
- The Brain Resting-State Functional Connectivity Underlying Violence Proneness: Is It a Reliable Marker for Neurocriminology? A Systematic Review.Behavioral sciences (Basel, Switzerland) · 2019Review
- The goal priority network as a neural substrate of Conscientiousness.Human brain mapping · 2018Article
- Empirically derived patterns of psychiatric symptoms in youth: A latent profile analysis.Journal of affective disorders · 2017Article
- The Neural Correlates of Emotional Lability in Children with Autism Spectrum Disorder.Brain connectivity · 2017Article
- Default mode functional connectivity is associated with social functioning in schizophrenia.Journal of abnormal psychology · 2017Article
- Fronto-temporal connectivity predicts cognitive empathy deficits and experiential negative symptoms in schizophrenia.Human brain mapping · 2017Article
- A hierarchical causal taxonomy of psychopathology across the life span.Psychological bulletin · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The externalizing spectrum encompasses a range of maladaptive behaviors, including substance-use problems, impulsivity, and aggression. Although previous literature has linked externalizing behaviors with prefrontal and amygdala abnormalities, recent studies suggest insula functionality is implicated. This study investigated the relation between insula functional coherence and externalizing in a large community sample (N = 244). Participants underwent a resting functional MRI scan. Three nonartifactual intrinsic connectivity networks (ICNs) substantially involving the insula were identified after completing independent components analysis. Three externalizing domains-general disinhibition, substance abuse, and callous aggression-were measured with the Externalizing Spectrum Inventory. Regression models tested whether within-network coherence for the 3 insula ICNs was related to each externalizing domain. Posterior insula coherence was positively associated with general disinhibition and substance abuse. Anterior insula/ventral striatum/anterior cingulate network coherence was negatively associated with general disinhibition. Insula coherence did not relate to the callous aggression domain. Follow-up analyses indicated specificity for insula ICNs in their relation to general disinhibition and substance abuse as compared with other frontal and limbic ICNs. This study found insula network coherence was significantly associated with externalizing behaviors in community participants. Frontal and limbic ICNs containing less insular cortex were not related to externalizing. Thus, the neural synchrony of insula networks may be central for understanding externalizing psychopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.