ArticleMagnetic resonance in medicine2016
Functional electron paramagnetic resonance imaging of ischemic rat heart: Monitoring of tissue oxygenation and pH.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
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- Compact 1 GHz electron paramagnetic resonance spectrometer and imager.The Review of scientific instruments · 2025Article
- SABRE-SHEATH Hyperpolarization of [1,5-ACS sensors · 2024Article
- Partial Acquisition of Spectral Projections Accelerates Four-dimensional Spectral-spatial EPR Imaging for Mouse Tumor Models: A Feasibility Study.Molecular imaging and biology · 2024Article
- Article
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- The role of acid sensing ion channels in the cardiovascular function.Frontiers in physiology · 2023Review
- Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensors.Journal of biological engineering · 2021Article
- Development of an L-band resonator optimized for fast scan EPR imaging of the mouse head.Magnetic resonance in medicine · 2021Article
- High fidelity triangular sweep of the magnetic field for millisecond scan EPR imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2021Article
- Merging Preclinical EPR Tomography with other Imaging Techniques.Cell biochemistry and biophysics · 2019Article
- Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration.Scientific reports · 2019Article
- Development of a fast-scan EPR imaging system for highly accelerated free radical imaging.Magnetic resonance in medicine · 2019Article
- In Vivo Extracellular pH Mapping of Tumors Using Electron Paramagnetic Resonance.Analytical chemistry · 2018Article
- Biomedical Applications of Graphene-Based Structures.Nanomaterials (Basel, Switzerland) · 2018Review
- A combined positron emission tomography (PET)-electron paramagnetic resonance imaging (EPRI) system: initial evaluation of a prototype scanner.Physics in medicine and biology · 2018Article
- Cellular accumulation and antioxidant activity of acetoxymethoxycarbonyl pyrrolidine nitroxides.Free radical research · 2018Article
- Resonators for In Vivo Imaging: Practical Experience.Applied magnetic resonance · 2017Article
- Hypoxia impairs agonist-induced integrin αScientific reports · 2017Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeElectron paramagnetic resonance (EPR) imaging in the spectral-spatial domain with application of soluble paramagnetic probes provides an opportunity for spatially resolved functional measurements of living objects. The purpose of this study was to develop EPR methods for visualization of oxygenation and acidosis of ischemic myocardium.
methodsEPR oxygen measurements were performed using isotopically substituted (2) H,(15) N-dicarboxyproxyl. The radical has an EPR line width of 320 mG and oxygen-induced line broadening of 0.53 mG/mm Hg, providing oxygen sensitivity down to 5 μM. pH measurements were performed using previously developed pH-sensitive imidazoline nitroxide. The radical has an EPR spectrum with pH-dependable hyperfine splitting, pK = 6.6, providing pH sensitivity of approximately 0.05 U in the physiological range.
resultsEPR imaging of isolated and perfused rat hearts was performed in the two-dimensional + spectral domain. The spatial resolution of the measurements was about 1.4 mm. Marked tissue hypoxia was observed in the ischemic area of the heart after occlusion of the left anterior descending coronary artery. Tissue oxygenation was partly restored upon reperfusion. EPR mapping of myocardial pH indicated acidosis of the ischemic area down to pH 6.7-6.8.
conclusionThis study demonstrates the capability of low-field EPR and the nitroxide spin probes for mapping of myocardial oxygenation and pH. The developed approaches might be used for noninvasive investigation of microenvironment on living objects. Magn Reson Med 76:350-358, 2016. © 2015 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.