Evidence map›Paper›PMID 26301829›Full record

ArticlePloS one2015

Self-Regulation of Anterior Insula with Real-Time fMRI and Its Behavioral Effects in Obsessive-Compulsive Disorder: A Feasibility Study.

Korhan Buyukturkoglu, Hans Roettgers, Jens Sommer, Mohit Rana, Leonie Dietzsch, Ezgi Belkis Arikan, Ralf Veit, Rahim Malekshahi, Tilo Kircher, Niels Birbaumer and 2 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
6.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  20. The Brain from Within.Frontiers in human neuroscience · 2016
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Korhan BuyukturkogluGraduate School of Neural & Behavioural Sciences, International Max Planck Research School, University of Tübingen, Tuebingen, Germany; Institute for Medical Psychology and Behavioural Neurobiology, University of Tuebingen, Tuebingen, Germany.
Hans RoettgersDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Jens SommerDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Mohit RanaGraduate School of Neural & Behavioural Sciences, International Max Planck Research School, University of Tübingen, Tuebingen, Germany; Institute for Medical Psychology and Behavioural Neurobiology, University of Tuebingen, Tuebingen, Germany; Department of Biomedical Engineering, University of Florida, Gainesville, Florida, United States of America.
Leonie DietzschDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Ezgi Belkis ArikanDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Ralf VeitInstitute for Medical Psychology and Behavioural Neurobiology, University of Tuebingen, Tuebingen, Germany.
Rahim MalekshahiGraduate School of Neural & Behavioural Sciences, International Max Planck Research School, University of Tübingen, Tuebingen, Germany; Institute for Medical Psychology and Behavioural Neurobiology, University of Tuebingen, Tuebingen, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Niels BirbaumerInstitute for Medical Psychology and Behavioural Neurobiology, University of Tuebingen, Tuebingen, Germany; Ospedale San Camillo, Istituto di Ricovero e Cura a Carattere Scientifico, Venezia, Italy.
Ranganatha SitaramInstitute for Medical Psychology and Behavioural Neurobiology, University of Tuebingen, Tuebingen, Germany; Department of Biomedical Engineering, University of Florida, Gainesville, Florida, United States of America.
Sergio RuizInstitute for Medical Psychology and Behavioural Neurobiology, University of Tuebingen, Tuebingen, Germany; Departamento de Psiquiatría, Escuela de Medicina, Centro Interdisciplinario de Neurociencia, Pontificia Universidad Católica de Chile, Santiago, Chile.
Philipps University of Marburg · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionObsessive-compulsive disorder (OCD) is a common and chronic condition that can have disabling effects throughout the patient's lifespan. Frequent symptoms among OCD patients include fear of contamination and washing compulsions. Several studies have shown a link between contamination fears, disgust over-reactivity, and insula activation in OCD. In concordance with the role of insula in disgust processing, new neural models based on neuroimaging studies suggest that abnormally high activations of insula could be implicated in OCD psychopathology, at least in the subgroup of patients with contamination fears and washing compulsions.

methodsIn the current study, we used a Brain Computer Interface (BCI) based on real-time functional magnetic resonance imaging (rtfMRI) to aid OCD patients to achieve down-regulation of the Blood Oxygenation Level Dependent (BOLD) signal in anterior insula. Our first aim was to investigate whether patients with contamination obsessions and washing compulsions can learn to volitionally decrease (down-regulate) activity in the insula in the presence of disgust/anxiety provoking stimuli. Our second aim was to evaluate the effect of down-regulation on clinical, behavioural and physiological changes pertaining to OCD symptoms. Hence, several pre- and post-training measures were performed, i.e., confronting the patient with a disgust/anxiety inducing real-world object (Ecological Disgust Test), and subjective rating and physiological responses (heart rate, skin conductance level) of disgust towards provoking pictures.

resultsResults of this pilot study, performed in 3 patients (2 females), show that OCD patients can gain self-control of the BOLD activity of insula, albeit to different degrees. In two patients positive changes in behaviour in the EDT were observed following the rtfMRI trainings. Behavioural changes were also confirmed by reductions in the negative valence and in the subjective perception of disgust towards symptom provoking images.

conclusionAlthough preliminary, results of this study confirmed that insula down-regulation is possible in patients suffering from OCD, and that volitional decreases of insula activation could be used for symptom alleviation in this disorder.

Indexed as

AdultAnxietyCerebral CortexEmotionsFearFeasibility StudiesFemaleHeart RateHumansLearningMagnetic Resonance ImagingMaleNeuroimagingObsessive-Compulsive DisorderRadiographySelf-Control

Identifiers

PMID26301829
PMCPMC4547706
OpenAlexW1927579337

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.