ArticleCell adhesion & migration2015
Cancer cell migration in 3D tissue: negotiating space by proteolysis and nuclear deformability.
Article in Cell adhesion & migration, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 66 citations in OpenAlex.
- Invasion dynamics of multifocal breast tumor spheroids in three-dimensional extracellular matrix.Biophysical journal · 2026Article
- Is there a link between fascia and cancer? From potential mechanisms to future treatment options.Frontiers in physiology · 2026Review
- Review
- Unjamming Transition as a Paradigm for Biomechanical Control of Cancer Metastasis.Cytoskeleton (Hoboken, N.J.) · 2025Review
- Cell jamming in a collagen-based interface assay is tuned by collagen density and proteolysis.Journal of cell science · 2023Article
- Indentation induces instantaneous nuclear stiffening and unfolding of nuclear envelope wrinkles.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mesenchymal Migration on Adhesive-Nonadhesive Alternate Surfaces in Macrophages.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina.eLife · 2022Article
- Actomyosin contractility requirements and reciprocal cell-tissue mechanics for cancer cell invasion through collagen-based channels.The European physical journal. E, Soft matter · 2022Article
- The impact of the spatial heterogeneity of resistant cells and fibroblasts on treatment response.PLoS computational biology · 2022Article
- Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction.Frontiers in cell and developmental biology · 2022Review
- The Hallmarks of Cancer as Ecologically Driven Phenotypes.Frontiers in ecology and evolution · 2021Article
- The mechanics and dynamics of cancer cells sensing noisy 3D contact guidance.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
- On the role of predicted in vivo mitral valve interstitial cell deformation on its biosynthetic behavior.Biomechanics and modeling in mechanobiology · 2021Article
- From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research.Life (Basel, Switzerland) · 2020Review
- Lamin A/C and the Immune System: One Intermediate Filament, Many Faces.International journal of molecular sciences · 2020Review
- The promise of single-cell mechanophenotyping for clinical applications.Biomicrofluidics · 2020Article
- Biomarkers to quantify cell migration characteristics.Cancer cell international · 2020Article
- Inhomogeneities in 3D Collagen Matrices Impact Matrix Mechanics and Cancer Cell Migration.Frontiers in cell and developmental biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efficient tumor cell invasion into the surrounding desmoplastic stroma is a hallmark of cancer progression and involves the navigation through available small tissue spaces existent within the dense stromal network. Such navigation includes the reciprocal adaptation of the moving tumor cell, including the nucleus as largest and stiffest organelle, to pre-existent or de-novo generated extracellular matrix (ECM) gaps, pores and trails within stromal compartments. Within the context of migration, we briefly summarize physiological and tumor-related changes in ECM geometries as well as tissue proteolysis. We then focus on mechanisms that ensure the successful translocation of a nucleus through a confining pore by cytoskeleton-mediated coupling, as well as regulators of cell and nuclear deformability such as chromatin organization and nuclear lamina expression. In summary, understanding dynamic nuclear mechanics during migration in response to confined space will add to a better conceptual appreciation of cancer invasion and progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.