ArticleNature neuroscience2015
Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.
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Who cites it
127 citing papers in PubMed.
- The Computational, Pharmacological, and Physiological Determinants of Sensory Learning under Uncertainty.Current biology : CB · 2021Trial
- Regulation of the decision threshold by the locus coeruleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Association learning drives synaptic plasticity at feedforward synapses in somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Explainable machine learning identifies candidate shared neuroanatomical features in Alzheimer's and Parkinson's via importance inversion transfer.bioRxiv : the preprint server for biology · 2026Article
- Noradrenaline causes a spread of association in the hippocampal cognitive map.Nature communications · 2026Article
- The role of the locus coeruleus in eye movements during perceptual decision making.bioRxiv : the preprint server for biology · 2026Article
- Pupil size predicts exploration through critical slowing in prefrontal dynamics.Communications biology · 2025Article
- Pupil size predicts the onset of exploration and changes in prefrontal dynamics.bioRxiv : the preprint server for biology · 2025Article
- Distinct cortical encoding of acoustic and electrical cochlear stimulation.bioRxiv : the preprint server for biology · 2025Article
- The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input.PLoS biology · 2025Article
- Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making.Science advances · 2025Article
- Vagus nerve stimulation as a predictive coding modulator that enhances feedforward over feedback transmission.Frontiers in neural circuits · 2025Review
- Speech paired vagus nerve stimulation restores neural sound processing in a rat model of autism.Frontiers in neuroscience · 2025Article
- Noradrenaline Regulation of Brain-Body Communication.Advances in experimental medicine and biology · 2025Review
- Optogenetic inhibition of the locus coeruleus blocks vagus nerve stimulation-induced enhancement of extinction of conditioned fear in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Article
- Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning.Nature neuroscience · 2024Article
- Effects of Phasic Activation of Locus Ceruleus on Cortical Neural Activity and Auditory Discrimination Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Frontal Norepinephrine Represents a Threat Prediction Error Under Uncertainty.Biological psychiatry · 2024Article
- Stability of cross-sensory input to primary somatosensory cortex across experience.bioRxiv : the preprint server for biology · 2024Article
67 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
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Abstract
The cerebral cortex is plastic and represents the world according to the significance of sensory stimuli. However, cortical networks are embodied in complex circuits, including neuromodulatory systems such as the noradrenergic locus coeruleus, providing information about internal state and behavioral relevance. Although norepinephrine is important for cortical plasticity, it is unknown how modulatory neurons themselves respond to changes of sensory input. We examined how locus coeruleus neurons are modified by experience and the consequences of locus coeruleus plasticity for cortical representations and sensory perception. We made whole-cell recordings from rat locus coeruleus and primary auditory cortex (A1), pairing sounds with locus coeruleus activation. Although initially unresponsive, locus coeruleus neurons developed and maintained auditory responses afterwards. Locus coeruleus plasticity induced changes in A1 responses lasting at least hours and improved auditory perception for days to weeks. Our results demonstrate that locus coeruleus is highly plastic, leading to substantial changes in regulation of brain state by norepinephrine.
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