ArticleTranslational perioperative and pain medicine2015
Updated Mechanisms of Sickle Cell Disease-Associated Chronic pain.
Article in Translational perioperative and pain medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pharmacological interventions for painful sickle cell vaso-occlusive crises in adults.The Cochrane database of systematic reviews · 2019Pooled it
- Interventions for treating neuropathic pain in people with sickle cell disease.The Cochrane database of systematic reviews · 2019Pooled it
- Preliminary Benefits of In-Home Virtual Reality for Chronic Pain in Sickle Cell Disease: Pilot Randomized Trial.Biomedicines · 2026Article
- Pharmacogenomics and Opioid Efficacy in Sickle Cell Disease.Medicina (Kaunas, Lithuania) · 2026Review
- The Evaluation of Patient-Controlled Analgesia Compared to Standard Opioid Analgesic Therapy in Pain Management Among Patients With Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol.Health science reports · 2025Article
- A review on disease modifying pharmacologic therapies for sickle cell disease.Annals of hematology · 2025Review
- Inhibition of DAGLβ as a therapeutic target for pain in sickle cell disease.Haematologica · 2023Article
- Mechanisms of pain in sickle cell disease.British journal of pain · 2021Article
- Updated mechanisms underlying sickle cell disease-associated pain.Neuroscience letters · 2019Review
- A Qualitative Study of Chronic Pain and Self-Management in Adults with Sickle Cell Disease.Journal of the National Medical Association · 2019Article
- Age-Dependent Sexual Dimorphism in Susceptibility to Develop Chronic Pain in the Rat.Neuroscience · 2018Article
- The AVPR1A Gene and Its Single Nucleotide Polymorphism rs10877969: A Literature Review of Associations with Health Conditions and Pain.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2018Review
- The effect of hypnosis on pain and peripheral blood flow in sickle-cell disease: a pilot study.Journal of pain research · 2017Article
- Endothelin receptor antagonists in sickle cell disease: A promising new therapeutic approach.Life sciences · 2016Review
- Yoga Module Development and Validation for Sickle Cell Disease.International journal of yogaArticle
- Article
- Prevalence and predictors of chronic pain intensity and disability among adults with sickle cell disease.Health psychology openArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Sickle cell disease (SCD), a hemoglobinopathy, causes sickling of red blood cells, resulting in vessel blockage, stroke, anemia, inflammation, and extreme pain. A vast majority of SCD patients experience pain on a chronic basis, and many turn to opioids to provide limited relief. The side effects that come with chronic opioid use push for research into understanding the specific mechanisms of SCD-associated chronic pain. Current advances in SCD-associated pain have focused on alterations in the pain pathway including nociceptor sensitization and endogenous pain inducers. This article reviews the underlying pathophysiology of SCD, potential pain mechanisms, current treatments and their mechanism of action, and future directions of SCD-associated pain management. The information provided could help propel research in SCD-associated chronic pain and uncover novel treatment options for clinicians.
Indexed as
Identifiers
26301256PMC4542088What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.