ArticleBioMed research international2015
ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Polyphenols: A top-down approach to nutrition and depression.World journal of psychiatry · 2025Review
- Resveratrol, EGCG and Vitamins Modulate Activated T Lymphocytes.Molecules (Basel, Switzerland) · 2021Article
- Polyphenols and Fish Oils for Improving Metabolic Health: A Revision of the Recent Evidence for Their Combined Nutraceutical Effects.Molecules (Basel, Switzerland) · 2021Review
- Preparation of resveratrol dry suspension and its immunomodulatory and anti-inflammatory activity in mice.Pharmaceutical biology · 2020Article
- Improvement of Resveratrol Effects When Combined with Rice Oil in Rat Models of Inflammation.Inflammation · 2020Article
- IL-6 in Osteoarthritis: Effects of Pine Stilbenoids.Molecules (Basel, Switzerland) · 2018Article
- Z-ligustilide and anti-inflammatory prostaglandins have common biological properties in macrophages and leukocytes.Nutrition & metabolism · 2018Article
- High Resolution NMR Spectroscopy as a Structural and Analytical Tool for Unsaturated Lipids in Solution.Molecules (Basel, Switzerland) · 2017Review
- Resveratrol distinctively modulates the inflammatory profiles of immune and endothelial cells.BMC complementary and alternative medicine · 2017Article
- Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy?Advances in nutrition (Bethesda, Md.) · 2016Review
- Resveratrol and Omega-3 Fatty Acid: Its Implications in Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ω-3 PUFAs and polyphenols have multiple effects on inflammation in vivo and in vitro. The effects of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and resveratrol (RV) were investigated in LPS-stimulated peripheral blood leukocytes (PBLs) (i.e., acute inflammation) and IL-1β activated human chondrocytes (i.e., chronic inflammation). Inflammatory mediators including chemokines, cytokines, interleukins, and PGE2 were measured by multiplex analysis and gene expression was quantified by RT-PCR. In PBLs, RV decreased the secretion of PGE2, CCL5/RANTES, and CXCL8/IL-8 but increased IL-1β, IL-6, and IL-10. In contrast to RV, ω-3 PUFAs augmented the production of PGE2 and CXCL8/IL-8. EPA and DHA similarly affected the pattern of inflammatory mediators. Combination of RV and ω-3 PUFAs exerted synergistic effects on CCL5/RANTES and had additive effects on IL-6 or CXCL8/IL-8. Both ω-3 PUFAs and RV reduced catabolic gene expression (e.g., MMPs, ADAMTS-4, IL-1β, and IL-6) in activated chondrocytes. The data suggest that ω-3 PUFAs and RV differ in the regulation of acute inflammation of peripheral blood leukocytes but have common properties in modulating features related to chronic inflammation of chondrocytes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.