ReviewFrontiers in molecular biosciences2015
Computational approaches for inferring the functions of intrinsically disordered proteins.
Review in Frontiers in molecular biosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- Evaluation of predictions of disordered binding regions in the CAID2 experiment.Computational and structural biotechnology journal · 2025Review
- Availability of web servers significantly boosts citations rates of bioinformatics methods for protein function and disorder prediction.Bioinformatics advances · 2023Article
- Compositional Bias of Intrinsically Disordered Proteins and Regions and Their Predictions.Biomolecules · 2022Article
- Disordered-Ordered Protein Binary Classification by Circular Dichroism Spectroscopy.Frontiers in molecular biosciences · 2022Article
- flDPnn: Accurate intrinsic disorder prediction with putative propensities of disorder functions.Nature communications · 2021Article
- CheSPI: chemical shift secondary structure population inference.Journal of biomolecular NMR · 2021Article
- Comparative Assessment of Intrinsic Disorder Predictions with a Focus on Protein and Nucleic Acid-Binding Proteins.Biomolecules · 2020Review
- Enhanced Molecular Dynamics Simulations of Intrinsically Disordered Proteins.Methods in molecular biology (Clifton, N.J.) · 2020Article
- DISOselect: Disorder predictor selection at the protein level.Protein science : a publication of the Protein Society · 2020Article
- Analyzing IDPs in Interactomes.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Recent Advances in Computational Protocols Addressing Intrinsically Disordered Proteins.Biomolecules · 2019Review
- Dissociation of the Dimer of the Intrinsically Disordered Domain of RNase Y upon Antibody Binding.Biophysical journal · 2018Article
- To be disordered or not to be disordered: is that still a question for proteins in the cell?Cellular and molecular life sciences : CMLS · 2017Review
- Translational effects and coding potential of an upstream open reading frame associated with DOPA Responsive Dystonia.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Structural Basis of the Substrate Specificity and Enzyme Catalysis of aFrontiers in molecular biosciences · 2017Article
- Dynamics of the Extended String-Like Interaction of TFIIE with the p62 Subunit of TFIIH.Biophysical journal · 2016Article
- Order, Disorder, and Everything in Between.Molecules (Basel, Switzerland) · 2016Review
- Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum.The Journal of biological chemistry · 2016Review
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrinsically disordered proteins (IDPs) are ubiquitously involved in cellular processes and often implicated in human pathological conditions. The critical biological roles of these proteins, despite not adopting a well-defined fold, encouraged structural biologists to revisit their views on the protein structure-function paradigm. Unfortunately, investigating the characteristics and describing the structural behavior of IDPs is far from trivial, and inferring the function(s) of a disordered protein region remains a major challenge. Computational methods have proven particularly relevant for studying IDPs: on the sequence level their dependence on distinct characteristics determined by the local amino acid context makes sequence-based prediction algorithms viable and reliable tools for large scale analyses, while on the structure level the in silico integration of fundamentally different experimental data types is essential to describe the behavior of a flexible protein chain. Here, we offer an overview of the latest developments and computational techniques that aim to uncover how protein function is connected to intrinsic disorder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.