Evidence map›Paper›PMID 26301182›Full record

ArticleWorld journal of orthopedics2015

Persistent post-surgical pain and neuropathic pain after total knee replacement.

Georgios I Drosos, Triantafilia Triantafilidou, Athanasios Ververidis, Cristina Agelopoulou, Theodosia Vogiatzaki, Konstantinos Kazakos

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of orthopedics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03973177 (Phenol Neurolysis of Genicular Nerves for Chronic Knee Pain Following Total Knee Arthroplasty), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03973177 phase4withdrawnnot on this mapstarted 2019, after this paper: background citation

Phenol Neurolysis of Genicular Nerves for Chronic Knee Pain Following Total Knee Arthroplasty: a Pilot Prospective, Randomized, Crossover Trial

TypeinterventionalSponsorNorthwestern UniversityRan2019 to 2023Enrolled0ConditionsPain, ChronicArmsPhenol Injection, Methylprednisolone Injection
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 36 citations in OpenAlex.

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  9. Behavioral, Psychological, Neurophysiological, and Neuroanatomic Determinants of Pain.The Journal of bone and joint surgery. American volume · 2020
    Review
  10. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Georgios I DrososGeorgios I Drosos, Triantafilia Triantafilidou, Athanasios Ververidis, Konstantinos Kazakos, Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece.
Triantafilia TriantafilidouGeorgios I Drosos, Triantafilia Triantafilidou, Athanasios Ververidis, Konstantinos Kazakos, Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece.
Athanasios VerveridisGeorgios I Drosos, Triantafilia Triantafilidou, Athanasios Ververidis, Konstantinos Kazakos, Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece.
Cristina AgelopoulouGeorgios I Drosos, Triantafilia Triantafilidou, Athanasios Ververidis, Konstantinos Kazakos, Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece.
Theodosia VogiatzakiGeorgios I Drosos, Triantafilia Triantafilidou, Athanasios Ververidis, Konstantinos Kazakos, Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece.
Konstantinos KazakosGeorgios I Drosos, Triantafilia Triantafilidou, Athanasios Ververidis, Konstantinos Kazakos, Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece.
Democritus University of Thrace · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo study the prevalence of persistent post-surgical pain (PPSP) and neuropathic pain (NP) after total knee replacement (TKR).

methodsMEDLINE and Embase databases were searched for articles published until December 2014 in English language. Published articles were included if they referred to pain that lasts at least 3 mo after primary TKR for knee osteoarthritis, and measured pain with pain specific instruments. Studies that referred to pain caused by septic reasons and implant malalignment were excluded. Both prospective and retrospective studies were included and only 14 studies that match the inclusion criteria were selected for this review.

resultsThe included studies were characterized by the heterogeneity on the scales used to measure pain and pre-operative factors related to PPSP and NP. The reported prevalence of PPSP and NP seems to be relatively high, but it varies among different studies. There is also evidence that the prevalence of post-surgical pain is related to the scale used for pain measurement. The prevalence of PPSP is ranging at 6 mo from 16% to 39% and at 12 mo from 13.1% to 23% and even 38% of the patients. The prevalence of NP at 6 mo post-operatively is ranging from 5.2% to 13%. Pre-operative factors related to the development of PPSP also differ, including emotional functioning, such as depression and pain catastrophizing, number of comorbidities, pain problems elsewhere and operations in knees with early grade of osteoarthritis.

conclusionNo firm conclusions can be reached regarding the prevalence of PPSP and NP and the related factors due to the heterogeneity of the studies.

Indexed as

Chronic painNeuropathic painPainPersistent post-surgical painPost-operative painTotal knee replacement

Identifiers

PMID26301182
PMCPMC4539476
OpenAlexW1276167081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.