ArticleCurrent addiction reports2015
Genetic and Environmental Interplay in Adolescent Substance Use Disorders.
Article in Current addiction reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relationship Between Childhood Physical and Sexual Abuse and Adolescent Cannabis Use: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- The interplay between externalizing disorders polygenic risk scores and contextual factors on the development of marijuana use disorders.Drug and alcohol dependence · 2018Trial
- Ecological momentary assessments and interventions for youth substance use across clinical settings: A systematic review.Research square · 2026Article
- Review
- Parental substance use history density and its influence on reward anticipation brain activation in late childhood and early adolescence.Developmental cognitive neuroscience · 2025Article
- Polygenic Risk for Substance Use Disorders as Predictors of Substance Use Initiation Among African American Youth.Journal of studies on alcohol and drugs · 2025Article
- Scoping review of biological and psychosocial pathways that lead from childhood adversity to early-onset substance use.Frontiers in psychiatry · 2025Review
- Weighted Family History Density of Substance Use: Influence on Participant Substance Use Onset, Duration, and Escalation.Substance abuse and rehabilitation · 2025Article
- Social and Environmental Predictors of Youth Alcohol and Cannabis Initiation Risk: The Moderating Role of Family History of Substance Use Disorders.Substance use & misuse · 2025Article
- Rewiring the future: drugs abused in adolescence may predispose to mental illness in adult life by altering dopamine axon growth.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Adverse childhood experiences and adolescent cannabis use trajectories: findings from a longitudinal UK birth cohort.The Lancet. Public health · 2023Article
- Teenagers and Precision Psychiatry: A Window of Opportunity.Public health genomics · 2021Article
- Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates.Frontiers in human neuroscience · 2020Article
- Methodological Advances in Leveraging Neuroimaging Datasets in Adolescent Substance Use Research.Current addiction reports · 2019Article
- The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.Current addiction reports · 2019Article
- Tobacco and cannabis use in college students are predicted by sex-dimorphic interactions between MAOA genotype and child abuse.CNS neuroscience & therapeutics · 2019Article
- Contributions of an Internalizing Symptoms Polygenic Risk Score and Contextual Factors to Alcohol-Related Disorders in African American Young Adults.Journal of studies on alcohol and drugs · 2019Article
- Longitudinal associations between youth tobacco and substance use in waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study.Drug and alcohol dependence · 2018Article
- The Speed of Progression to Tobacco and Alcohol Dependence: A Twin Study.Behavior genetics · 2018Article
- Socioeconomic status is associated with the prevalence and co-occurrence of risk factors for cigarette smoking initiation during adolescence.International journal of public health · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Adolescent substance use is of considerable public health importance. This narrative review provides a brief background to genetically informative research methodologies and highlights key recent literature examining the interplay between genetic and environmental influences in the etiology of substance use. Twin studies have quantified the magnitude of genetic and environmental influences, and more recently co-relative and Children of Twin designs have shown environments can moderate heritability. Studies have identified a number of specific gene variants (e.g. OPRM1, DRD4, 5HTTLPR) that interact with parenting and peer influence, and the effectiveness of interventions may vary by genotype. However, little research has taken into account the stage-sequential nature of substance use. This may obscure important differences in the genetic and environmental influences, and their interplay, at the stages of escalation to problem use. Future research needs to build on existing methodologies to disentangle the complexities of progression in adolescent substance use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.