Evidence map›Paper›PMID 26301071›Full record

ArticleTherapeutic advances in drug safety2015

hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes.

Jules C Hancox, Dario Melgari, Christopher E Dempsey, Kieran E Brack, John Mitcheson, G André Ng

Abstract read
In one paragraph

Article in Therapeutic advances in drug safety, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Acute on Chronic Ivabradine Overdose: a Case Report.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2016
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jules C HancoxSchool of Physiology and Pharmacology, Medical Sciences Building, University of Bristol, University Walk, Bristol BS8 1TD, UK.
Dario MelgariSchool of Physiology and Pharmacology, University of Bristol, Bristol, UK.
Christopher E DempseySchool of Biochemistry, University of Bristol, Bristol, UK.
Kieran E BrackDepartment of Cardiovascular Sciences, Cardiology Group, University of Leicester, Glenfield Hospital, Leicester, UK.
John MitchesonDepartment of Cell Physiology and Pharmacology, University of Leicester, Leicester, UK.
G André NgDepartment of Cardiovascular Sciences, Cardiology Group, University of Leicester, Glenfield Hospital, Leicester, and National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Leicester, UK.
University of Bristol · GBGlenfield Hospital · GBUniversity of Leicester · GB

Funding

British Heart Foundation FS/11/59/28938British Heart Foundation FS/12/2/29300British Heart Foundation FS/12/52/29629British Heart Foundation PG/11/38/28886British Heart Foundation PG/13/57/30385
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID26301071
PMCPMC4530352
OpenAlexW2129923821

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.