ArticleOxidative medicine and cellular longevity2015
Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator.
Article in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Remote intestinal changes following blast-induced thoracic trauma with transient hemorrhagic shock and hind-limb ischemia.Intensive care medicine experimental · 2026Article
- Polydatin: A natural compound with multifaceted anticancer properties.Journal of traditional and complementary medicine · 2025Review
- SIRT1-Mediated HMGB1 Deacetylation Suppresses Neutrophil Extracellular Traps Related to Blood-Brain Barrier Impairment After Cerebral Venous Thrombosis.Molecular neurobiology · 2024Article
- MKK3 depletion attenuates intestinal injury after traumatic hemorrhagic shock by restoring mitochondrial function.Molecular biology reports · 2024Article
- Article
- Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits.Molecules (Basel, Switzerland) · 2022Review
- [Polydatin improves intestinal barrier injury after traumatic brain injury in rats by reducing oxidative stress and inflammatory responseNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs.Frontiers in pharmacology · 2022Article
- SIRT1 Activation by Polydatin Alleviates Oxidative Damage and Elevates Mitochondrial Biogenesis in Experimental Diabetic Neuropathy.Cellular and molecular neurobiology · 2021Article
- Polydatin protects against lipopolysaccharide-induced endothelial barrier disruption via SIRT3 activation.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Protective Effect of Polydatin on Jejunal Mucosal Integrity, Redox Status, Inflammatory Response, and Mitochondrial Function in Intrauterine Growth-Retarded Weanling Piglets.Oxidative medicine and cellular longevity · 2020Article
- Polydatin prevents the induction of secondary brain injury after traumatic brain injury by protecting neuronal mitochondria.Neural regeneration research · 2019Article
- Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.Biochimica et biophysica acta. Molecular basis of disease · 2019Article
- Evidence for SIRT1 Mediated HMGB1 Release From Kidney Cells in the Early Stages of Hemorrhagic Shock.Frontiers in physiology · 2019Article
- Microcirculatory Disorders and Protective Role of Xuebijing in Severe Heat Stroke.Scientific reports · 2018Article
- Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells.Oxidative medicine and cellular longevity · 2017Review
- Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury.Molecular medicine reports · 2016Article
- SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model.Oxidative medicine and cellular longevity · 2016Article
- Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation.Oxidative medicine and cellular longevity · 2016Article
- Polydatin Protecting Kidneys against Hemorrhagic Shock-Induced Mitochondrial Dysfunction via SIRT1 Activation and p53 Deacetylation.Oxidative medicine and cellular longevity · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the role of SIRT1 in small intestine damage following severe hemorrhagic shock and to investigate whether polydatin (PD) can activate SIRT1 in shock treatment. RESEARCH DESIGN AND
methodsThe severe hemorrhagic shock model was reproduced in Sprague Dawley rats.
main outcome measuresTwo hours after drug administration, half of the rats were assessed for survival time evaluation and the remainder were used for small intestinal tissue sample collection.
resultsBleeding and swelling appeared in the small intestine with epithelial apoptosis and gut barrier disturbance during hemorrhagic shock. SIRT1 activity and PGC-1α protein expression of the small intestine were decreased, which led to an increase in acetylated SOD2 and decreases in the expression and activity of SOD2, resulting in severe oxidative stress. The decreased SIRT1 activity and expression were partially restored in the PD administration group, which showed reduced intestine injury and longer survival time. Notably, the effect of PD was abolished after the addition of Ex527, a selective inhibitor of SIRT1.
conclusionsThe results collectively suggest a role for the SIRT1-PGC-1α-SOD2 axis in small intestine injury following severe hemorrhagic shock and that PD is an effective SIRT1 activator for the shock treatment.
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