ArticleFrontiers in microbiology2015
Distinct stages during colonization of the mouse gastrointestinal tract by Candida albicans.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Comparative Analysis of the Fitness of Candida albicans Strains During Colonization of the Mice Gastrointestinal Tract.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Absence of Bacteria Permits Fungal Gut-To-Brain Translocation and Invasion in Germfree Mice but Ageing Alone Does Not Drive Pathobiont Expansion in Conventionally Raised Mice.Frontiers in aging neuroscience · 2022Article
- Bile Acid Regulates the Colonization and Dissemination ofJournal of fungi (Basel, Switzerland) · 2021Article
- Identification of Clinical Isolates ofJournal of fungi (Basel, Switzerland) · 2021Article
- The Glyoxylate Cycle Is Involved in White-Opaque Switching inJournal of fungi (Basel, Switzerland) · 2021Article
- Human papillomavirus infection and cervical intraepithelial neoplasia progression are associated with increased vaginal microbiome diversity in a Chinese cohort.BMC infectious diseases · 2020Article
- The gut, the bad and the harmless: Candida albicans as a commensal and opportunistic pathogen in the intestine.Current opinion in microbiology · 2020Review
- Advances in Molecular Tools and In Vivo Models for the Study of Human Fungal Pathogenesis.Microorganisms · 2020Review
- Association between the vaginal microbiome and high-risk human papillomavirus infection in pregnant Chinese women.BMC infectious diseases · 2019Article
- Review
- Article
- Systematic gene overexpression in Candida albicans identifies a regulator of early adaptation to the mammalian gut.Cellular microbiology · 2018Article
- Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Overexpression of the Transcriptional RegulatorFrontiers in cellular and infection microbiology · 2017Article
- The Candida albicans Pho4 Transcription Factor Mediates Susceptibility to Stress and Influences Fitness in a Mouse Commensalism Model.Frontiers in microbiology · 2016Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Candida albicans is a member of the human microbiota, colonizing both the vaginal and gastrointestinal tracts. This yeast is devoid of a life style outside the human body and the mechanisms underlying the adaptation to the commensal status remain to be determined. Using a model of mouse gastrointestinal colonization, we show here that C. albicans stably colonizes the mouse gut in about 3 days starting from a dose as low as 100 cells, reaching steady levels of around 10(7) cells/g of stools. Using fluorescently labeled strains, we have assessed the competition between isogenic populations from different sources in cohoused animals. We show that long term (15 days) colonizing cells have increased fitness in the gut niche over those grown in vitro or residing in the gut for 1-3 days. Therefore, two distinct states, proliferation and adaptation, seem to exist in the adaptation of this fungus to the mouse gut, a result with potential significance in the prophylaxis and treatment of Candida infections.
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