ArticleFrontiers in microbiology2015
Regulation of biofilm formation by BpfA, BpfD, and BpfG in Shewanella oneidensis.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- Conjugated Polymer-Microbe Interactions Trigger Regulatory Reprogramming for Enhanced Bioelectrocatalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Ampicillin promotes the biofilm formation ofMicrobiology spectrum · 2026Article
- Local c-di-GMP signaling, triggered by cross-regulation of cAMP-CRP and c-di-GMP, controls biofilm formation under nutrient limitation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- BpfD Is a c-di-GMP Effector Protein Playing a Key Role for Pellicle Biosynthesis inInternational journal of molecular sciences · 2024Article
- Bovine Serum Albumin Bends Over Backward to Interact with Aged Plastics: A Model for Understanding Protein Attachment to Plastic Debris.Environmental science & technology · 2024Article
- Insights into the biosynthesis of palladium nanoparticles for oxygen reduction reaction by genetically engineered bacteria of Shewanella oneidensis MR-1.Microbial biotechnology · 2024Article
- Review
- The Pseudomonas aeruginosa Biofilm Matrix Protein CdrA Has Similarities to Other Fibrillar Adhesin Proteins.Journal of bacteriology · 2023Review
- Biofilm Signaling, Composition and Regulation inJournal of microbiology and biotechnology · 2023Review
- Article
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- GGDEF domain as spatial on-switch for a phosphodiesterase by interaction with landmark protein HubP.NPJ biofilms and microbiomes · 2022Article
- Genomic Analysis of Two Representative Strains ofFoods (Basel, Switzerland) · 2022Article
- cAMP and c-di-GMP synergistically support biofilm maintenance through the direct interaction of their effectors.Nature communications · 2022Article
- Microbial fuel cells and their electrified biofilms.Biofilm · 2021Article
- Microbial Electrochemical Systems: Principles, Construction and Biosensing Applications.Sensors (Basel, Switzerland) · 2021Review
- LapG mediates biofilm dispersal in Vibrio fischeri by controlling maintenance of the VCBS-containing adhesin LapV.Molecular microbiology · 2020Article
- Elevated intracellular cyclic-di-GMP level in Shewanella oneidensis increases expression of c-type cytochromes.Microbial biotechnology · 2020Article
- From Input to Output: The Lap/c-di-GMP Biofilm Regulatory Circuit.Annual review of microbiology · 2020Review
- Flagellation of Shewanella oneidensis Impacts Bacterial Fitness in Different Environments.Current microbiology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria switch between two distinct life styles - planktonic (free living) and biofilm forming - in keeping with their ever-changing environment. Such switch involves sophisticated signaling and tight regulation, which provides a fascinating portal for studying gene function and orchestrated protein interactions. In this work, we investigated the molecular mechanism underlying biofilm formation in Shewanella oneidensis MR-1, an environmentally important model bacterium renowned for respiratory diversities, and uncovered a gene cluster coding for seven proteins involved in this process. The three key proteins, BpfA, BpfG, and BpfD, were studied in detail for the first time. BpfA directly participates in biofilm formation as extracellular "glue" BpfG is not only indispensable for BpfA export during biofilm forming but also functions to turn BpfA into active form for biofilm dispersing. BpfD regulates biofilm development by interacting with both BpfA and BpfG, likely in response to signal molecule c-di-GMP. In addition, we found that 1:1 stoichiometry between BpfD and BpfG is critical for biofilm formation. Furthermore, we demonstrated that a biofilm over-producing phenotype can be induced by C116S mutation but not loss of BpfG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.