ReviewFrontiers in neurology2015
Deep Brain Stimulation in Tourette's Syndrome.
Review in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Bridging the Gap in FDA Approval for Pediatric Neuromodulation Devices.Children (Basel, Switzerland) · 2025Review
- Comparison of children and adults in deep brain stimulation for Tourette Syndrome: a large-scale multicenter study of 102 cases with long-term follow-up.BMC medicine · 2024Article
- Stereotactic Surgery for Treating Intractable Tourette Syndrome: A Single-Center Pilot Study.Brain sciences · 2022Article
- Pre-Clinical Development of Robot-Assisted Ventriculoscopy for 3D Image Reconstruction and Guidance of Deep Brain Neurosurgery.IEEE transactions on medical robotics and bionics · 2022Article
- Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit.Translational psychiatry · 2018Article
- Enriched Environment Facilitates Anxiolytic Efficacy Driven by Deep-Brain Stimulation of Medial Prefrontal Cortex.Frontiers in behavioral neuroscience · 2018Article
- The Use of Deep Brain Stimulation in Tourette Syndrome.Brain sciences · 2016Review
- Recent Advances in Understanding and Managing Tourette Syndrome.F1000Research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTourette's syndrome (TS) is defined by 1 year of persistent motor and vocal tics. Often, the tics are refractory to conventional pharmacologic and psychobehavioral interventions. In these patients, deep brain stimulation (DBS) may be an appropriate intervention. This paper reviews different DBS targets in TS, discusses existing evidence on the efficacy of DBS in TS, highlights adverse effects of the procedure, discusses indications and patient selection as well as future directions for DBS in TS.
methodsA literature review searching PubMed database entries between 2000 and 2015. Search terms included "DBS in Tourette Syndrome", "Deep brain stimulation in Tourette syndrome," and "Surgical management of Tourette Syndrome."
resultsThough there are no universally accepted guidelines defining ideal DBS candidates for TS, age, tic severity, and treatment refractoriness are important factors to consider in patient selection. A variety of targets exist for DBS in TS, but thalamic targets and GPi are the most widely studied. Psychiatric side effects that are target specific should be monitored closely and it is possible that these adverse effects may be resolved with programing. Small randomized controlled trials support the efficacy of DBS in TS.
conclusionDBS for TS is safe and feasible, but large multi-center clinical trials are needed to determine the ideal target and optimal location within a particular target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.