Evidence map›Paper›PMID 26300790›Full record

ArticleFrontiers in psychiatry2015

Spreading Effect of tDCS in Individuals with Attention-Deficit/Hyperactivity Disorder as Shown by Functional Cortical Networks: A Randomized, Double-Blind, Sham-Controlled Trial.

Camila Cosmo, Cândida Ferreira, José Garcia Vivas Miranda, Raphael Silva do Rosário, Abrahão Fontes Baptista, Pedro Montoya, Eduardo Pondé de Sena

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01968512 (Neurobiological Aspects of the Attention Deficit Hyperactivity Disorder), which is not on this map. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01968512 nacompletednot on this map

Neurobiological Aspects of the Attention Deficit Hyperactivity Disorder: Contribution of the Transcranial Direct Current Stimulation in Control Inhibitory.

TypeinterventionalSponsorFederal University of BahiaRan2013 to 2014Enrolled60ConditionsAttention Deficit Hyperactivity DisorderArmsTranscranial Direct Current Stimulation, Sham
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. tDCS and neurofeedback in ADHD treatment.Frontiers in systems neuroscience · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Comparison between conventional and HD-tDCS of the right inferior frontal gyrus in children and adolescents with ADHD.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Camila CosmoPostgraduate Program, Interactive Process of Organs and Systems, Federal University of Bahia , Salvador , Brazil ; Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School , Boston, MA , USA ; Bahia State Department of Health (SESAB) , Salvador , Brazil ; Functional Electrostimulation Laboratory, Biomorphology Department, Federal University of Bahia , Salvador , Brazil.
Cândida FerreiraInstitute of Physics, Federal University of Bahia , Salvador , Brazil.
José Garcia Vivas MirandaInstitute of Physics, Federal University of Bahia , Salvador , Brazil.
Raphael Silva do RosárioInstitute of Physics, Federal University of Bahia , Salvador , Brazil.
Abrahão Fontes BaptistaFunctional Electrostimulation Laboratory, Biomorphology Department, Federal University of Bahia , Salvador , Brazil ; Postgraduate Program in Medicine and Human Health, School of Medicine, Federal University of Bahia , Salvador , Brazil.
Pedro MontoyaResearch Institute in Health Sciences (IUNICS-IdisPa), University of the Balearic Islands , Palma , Spain.
Eduardo Pondé de SenaPostgraduate Program, Interactive Process of Organs and Systems, Federal University of Bahia , Salvador , Brazil.
Universidade Federal da Bahia · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscranial direct current stimulation (tDCS) is known to modulate spontaneous neural network excitability. The cognitive improvement observed in previous trials raises the potential of this technique as a possible therapeutic tool for use in attention-deficit/hyperactivity disorder (ADHD) population. However, to explore the potential of this technique as a treatment approach, the functional parameters of brain connectivity and the extent of its effects need to be more fully investigated.

objectiveThe aim of this study was to investigate a functional cortical network (FCN) model based on electroencephalographic activity for studying the dynamic patterns of brain connectivity modulated by tDCS and the distribution of its effects in individuals with ADHD.

methodsSixty ADHD patients participated in a parallel, randomized, double-blind, sham-controlled trial. Individuals underwent a single session of sham or anodal tDCS at 1 mA of current intensity over the left dorsolateral prefrontal cortex for 20 min. The acute effects of stimulation on brain connectivity were assessed using the FCN model based on electroencephalography activity.

resultsComparing the weighted node degree within groups prior to and following the intervention, a statistically significant difference was found in the electrodes located on the target and correlated areas in the active group (p < 0.05), while no statistically significant results were found in the sham group (p ≥ 0.05; paired-sample Wilcoxon signed-rank test).

conclusionAnodal tDCS increased functional brain connectivity in individuals with ADHD compared to data recorded in the baseline resting state. In addition, although some studies have suggested that the effects of tDCS are selective, the present findings show that its modulatory activity spreads. Further studies need to be performed to investigate the dynamic patterns and physiological mechanisms underlying the modulatory effects of tDCS.

trial registrationClinicalTrials.gov NCT01968512.

Indexed as

attention-deficit/hyperactivity disorderdorsolateral prefrontal cortexfunctional cortical networksspreading effecttranscranial direct current stimulation

Identifiers

PMID26300790
PMCPMC4524049
OpenAlexW1897332711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.